Multi-organ chips connect multiple organ models via microfluidic circulation to study systemic drug effects, organ-organ interactions, and integrated ADME-Tox. These platforms represent the closest in vitro approximation of whole-body physiology, enabling prediction of complex pharmacokinetics and off-target effects.
PLATFORM CONFIGURATIONS
Intestine-liver connection models oral drug absorption and hepatic first-pass metabolism for bioavailability prediction.
Liver-kidney axis enables study of reactive metabolite nephrotoxicity and drug-drug interactions.
Advanced platforms (Hesperos, TissUse) connect 10+ organ models for comprehensive systemic assessment.
Blood-brain barrier integration enables CNS drug penetration and neurotoxicity studies.
KEY PROVIDERS
Hesperos
Original human-on-chip; 10+ organ systems
TissUse
HUMIMIC platform; Berlin-based
CN Bio
Multi-organ liver-centric systems