EVALUATION FRAMEWORK
Vendor selection should match your specific application needs. Consider scientific fit (does the model address your question?), operational requirements (throughput, expertise needed), regulatory pathway (validation status), and commercial terms (pricing model, IP rights). Pilot studies before commitment are essential.
KEY SELECTION CRITERIA
- Scientific Validation: Published data, pharma partnerships, regulatory submissions
- Model Complexity: Single organ vs. multi-organ, static vs. perfused, cell sources
- Throughput: Low-throughput mechanistic vs. high-throughput screening
- Technical Support: Training, protocol optimization, troubleshooting
- Cost Structure: Consumables, equipment, service fees, per-sample pricing
SERVICE MODELS
- Product Purchase: Buy platforms/consumables, run studies in-house (Emulate, CN Bio)
- CRO Services: Outsource studies to vendor laboratories (Crown Bioscience, InSphero)
- Hybrid: Vendor installs system on-site with ongoing support
- Biobank Access: License organoid lines from established collections (HUB)
- Co-Development: Joint development of custom models for specific applications
DUE DILIGENCE
Request reference customers in similar applications. Review published validation data critically. Understand IP implications—some platforms restrict data publication or require co-authorship. Negotiate data ownership upfront. Evaluate vendor financial stability for long-term partnerships. Site visits assess operational quality.