L'ORÉALLyon, FranceOECD Validated
Reconstructed Skin Pioneer

EpiSkin

L'Oréal's SkinEthic Reconstructed Tissue Models

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COMPANY OVERVIEW

EpiSkin SAS, a subsidiary of L'Oréal headquartered in Lyon, France, is a pioneer in reconstructed human tissue models. The company developed OECD-validated skin and cornea models for safety testing, supporting L'Oréal's commitment to eliminate animal testing while also commercializing products to the broader cosmetics and pharmaceutical industries.

PRODUCT PORTFOLIO

  • EpiSkin: Reconstructed human epidermis for skin irritation/corrosion testing
  • SkinEthic RHE: Reconstructed human epidermis models (OECD TG 439)
  • SkinEthic HCE: Human cornea-like epithelium for eye irritation (OECD TG 492)
  • SkinEthic RhE Pigmented: Melanocyte-containing models for skin lightening studies
  • SkinEthic HGE: Human gingival epithelium for oral care product testing

REGULATORY VALIDATION

  • OECD TG 431: EpiSkin validated for skin corrosion
  • OECD TG 439: EpiSkin and SkinEthic validated for skin irritation
  • OECD TG 492: SkinEthic HCE validated for eye irritation
  • EU Reference Methods: Listed in EU cosmetics regulation annexes

L'ORÉAL INTEGRATION

EpiSkin enables L'Oréal to maintain its leadership in cruelty-free cosmetics development, having screened over 4,000 ingredients and 600 products annually without animal testing. The models also support L'Oréal's personalized beauty initiatives through testing on diverse skin types and phototypes.

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