Live News Categories
ORGAN-ON-CHIP
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Recent Advances in Alternate Corneal Models for Ophthalmic Safety Testing and Efficacy Studies: A Special Focus on Organ-on-a-Chip, Organoid, and 3D Models
Muscle Organoids and Organs-on-Chips: A 15-Year Global Bibliometric Perspective
Hydrogels and microfluidics: toward more physiologically relevant organ-on-a-chip models
Three-dimensional cell culture models in oncology: From tumour spheroids to integrated microphysiological systems
hiPSC-derived Organoids and Organ-on-chip Systems: New Frontiers in Neural Tube Defect Research
Integration of multi-stacked biodegradable PLGA membranes into microfluidic organ-on-a-chip devices for tunable barrier co-culture
Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy
Metabolism-dependent drug response assessment using a liver-cancer microphysiological system on the kinetic-pump integrated microfluidic plate (KIM-Plate)
Integration of microphysiological systems with computational and digital twin modeling for pharmaceutical development: a systematic review
Bioengineered human brain organoids and organ-on-chip platforms for exposure-aware assessment of developmental neurotoxicity induced by general anesthetics and sedatives
Cisplatin-Resistant Lung Adenocarcinoma Cells Exhibit Increased Proangiogenic Capacity in a Microphysiological Model of Tumor Neovascularization
Reconstructing AF-associated atrial fibrosis: Patient-specific iPSC models, fit-for-purpose atrial microphysiological systems, and nanomedicine
Development of a Multi-Organ Microphysiological (MPS) Model to Study Age-Related Comorbidities
Human organoids and organ-on-chip systems for AI-guided therapeutic discovery against emerging and re-emerging infections
Exploring the Translation of Organ-on-a-Chip Technology for Human-Relevant Diagnostic Biomarkers
Microfluidic engineering of polymer-based drug delivery systems: From particle synthesis to organ-on-a-chip validation and application
New Dimensions in Diabetic Kidney Disease Research: Advanced Organoids and Organs-on-a-Chip
Organ-on-a-Chip Technology: Advances in Modeling Inflammation, Neurovascularization and Nociception in Human Intervertebral Disc Degeneration
Microphysiological immune-on-chip systems: engineering human immunity for precision immunotherapy, vaccine development, and autoimmune disease modelling
5 perspectives on translating microphysiological systems from concept to application
ORGANOIDS
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Author Correction: Single cell transcriptomic profiling of a neuron-astrocyte assembloid tauopathy model
Reconstruction of the hematopoietic system using bone marrow, thymus, and spleen organoids: Construction strategies and research advances
Recent Advances in Alternate Corneal Models for Ophthalmic Safety Testing and Efficacy Studies: A Special Focus on Organ-on-a-Chip, Organoid, and 3D Models
Cardiac Organoids for Modeling Congenital Heart Disease: From Genetic Discovery to Therapeutic Screening
Millifluidic triMEA organoid platform with stretchable microelectrode arrays for parallel organoid electrophysiology under standardized perfusion
Muscle Organoids and Organs-on-Chips: A 15-Year Global Bibliometric Perspective
Modular assembly of arterial organoids enables rapid blood perfusion to ameliorate ischemic diseases
Self-organizing human dual neural organoids model regional disease defects and teratogenicity
Using Brain Organoids to Explore Human Neurobiology
A human iPSC-based perfusable and membrane-free neurovascular unit-on-chip connecting brain organoids to the blood-brain barrier
Smart organoid-on-chip systems: From microfluidics to sensors, control, and AI
Development-inspired approach for the derivation of functional and transplantable salivary gland organoids from human pluripotent stem cells
Effects of commonly used pesticides and their mixtures on the upper airway epithelium using porcine organoid-derived models
Elevated glucose in kidney organoids induces tissue-intrinsic inflammation driving epithelial detachment
Novel functions of taste-like cells: Organoid-reconstructed sensory interfaces
Organoids Serve as Viable In Vitro Model for Functional Precision Medicine for Mesonephric-Like Adenocarcinoma of the Ovary
Kit-based remote collection and isolation of human reprogrammable somatic cells for generation of induced pluripotent stem cells and cerebral organoids
Developmental xenocortication using human-derived organoids in mice
Kit-based remote collection and isolation of human reprogrammable somatic cells for generation of induced pluripotent stem cells and cerebral organoids
Quantitative imaging of dynamic processes in intestinal organoids
DIGITAL TWINS
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Harnessing digital twins for public health surveillance and pandemic preparedness
Expanding research on clinical agent data to a virtual space of location, time, and context: exploration of data structures and limitations using a pragmatic digital twin
Accuracy of virtual patient reconstruction for complete arch implant-supported prostheses with extraoral scan body-assisted registration
Dynamic simulation and digital twins in atrial fibrillation: Complementary roles and current limitations
Artificial Intelligence-Driven Norepinephrine Control Using Adaptive Cardiac Digital Twin for Critical Care Patients
Artificial intelligence-driven digital twins in Pharma 4.0: transforming smart manufacturing, predictive quality assurance, and personalized drug delivery
Investigation of in vivo silk scaffold degradation by decoupling tissue ingrowth using a Gaussian process regression-driven digital twin framework
FedEC-Dia: Explanation-Calibrated Federated Learning for Patient-Level Diabetes Digital Twin Risk Prediction Under Non-IID Healthcare Data
A cellular Digital Twin framework for predictive and mechanistic modeling of drug responses in precision medicine
From self-quantification to predictive ageing: Digital twins as a framework for healthy ageing and longevity
Cross-fusion of digital twins and artificial intelligence in diabetes: from mechanistic elucidation to full-cycle precision management
Integration of microphysiological systems with computational and digital twin modeling for pharmaceutical development: a systematic review
Digital twins and systemic acceleration: insights from Luhmann's sociological perspective
Pre-Ramadan time-below-range stratifies the simulated pump basal-rate dose-response during Ramadan fasting: a five-policy paired virtual-patient study
Reframing chronic hepatitis B care through digital twin modelling
A Novel Tool to Create Digital Twin Temporal Bone Models for Virtual and 3D-Printing: Proof-of-Concept and Evaluation
CXCR4-centred signalling network rewiring distinguishes primary and metastatic prostate cancer: A systems-level digital twin framework
Structural requirements for intelligent clinical digital twins in feedback-driven care
Digital twin-enabled toxicology: Current applications, opportunities, and future directions
Digital twins are funhouse mirrors: Five systematic distortions
AI & MACHINE LEARNING
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Identification of Gene Signatures and Molecular Mechanisms Underlying the Comorbidity of Alzheimer's Disease and Crohn's Disease Using Machine Learning
Boehringer, Envisagenics sign $1B multi-target oncology collaboration
Building clinical fluency in artificial intelligence: basic knowledge for addiction medicine practitioners and researchers
Decision-curve analysis should be a bridge, not an endpoint, for clinical artificial intelligence in oncology
DeepGVS: a bimodal deep learning framework integrating coding-sequence and protein-structural representations for virulence factor prediction
Artificial Intelligence in Radiology: Methodological Foundations, Clinical Applications, and Emerging Multimodal Models
Early diagnosis and molecular classification of gastric cancer peritoneal metastasis by deep learning-driven single-cell lipidomics
AlloPool is a deep learning framework that infers protein allostery from molecular dynamics simulations
C-reactive protein-triglyceride-glucose index and incident mild cognitive impairment among patients with cardiovascular-kidney-metabolic syndrome: a dual-cohort prediction and double machine learning analysis
Inter-rater reliability in drug-induced sleep endoscopy: experience-driven interpretation, decision-making, and the emerging role of artificial intelligence
Toward scalable detection of clinical reasoning in supervision: A machine learning feasibility study
Toward Continuous, Multimodal Perioperative Intelligence: Translating Artificial Intelligence from Risk Prediction to Clinical Practice
Serum Protein Glycopatterns as Biomarkers for Machine Learning Diagnosis of Major Depressive Disorder
Plasma biomarker and machine learning modeling of clinical progression in cognitively normal individuals at risk for Alzheimer's disease
Postoperative Supraspinatus Muscle Volume Restoration Is Associated With Tendon Healing and Strength Recovery After Rotator Cuff Repair: Deep-Learning-Based Volumetric Analysis of the Entire Muscle With Clinical Correlation
Artificial intelligence in ophthalmology: From diagnostic accuracy to clinical application
Deciphering foliar uptake mechanisms of organophosphate esters in plant leaves: Molecular structure-cuticular wax interactions revealed by experimental evidence and machine learning
Classification of histology and molecular subtypes of brain gliomas and glioneuronal and neuronal tumors using a deep learning approach
[Tailoring care to the mind: The emerging role of artificial intelligence in precision psychiatry. Part I: Understanding, measuring and modelling clinical singularity]
Identification of immune cell mitochondrial dysfunction characteristics and clinical predictive biomarkers in sepsis via multi-cohort machine learning and single-cell RNA sequencing
CLINICAL TRIALS
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Celldex monoclonal antibody rebounds with pair of phase 3 wins for chronic skin condition
Roche’s GLP-1/GIP drug hits in phase 2 diabetes trial, fueling best-in-disease hopes
Early improvements in function with atogepant as assessed by the Activity Impairment in Migraine-Diary: Post hoc analyses of three randomized, phase 3 clinical trials of atogepant for the preventive treatment of migraine
Multimodal Facial Rejuvenation Using Integrated Radiofrequency, Microneedle Radiofrequency, and Dynamic Muscle Stimulation: A Prospective Randomized Controlled Trial
First patient dosed in Accro Bioscience’s Phase IIb AC-101 study
Response to the letter to the editor- phase III trials in retinal biosimilars: parity before pragmatism
Changes in perceived psychosocial working conditions after psychotherapeutic consultation at work - exploratory post-hoc analyses from a randomized controlled trial
Effect of β-tricalcium phosphate grafting on implant stability and peri-implant radiodensity following immediate implant placement in sites with jumping gaps exceeding 2 mm: a randomized controlled trial
Feasibility and acceptability of the Unified Protocol for anxiety and depression in Pakistan: a pilot randomized controlled trial
Modified single-stapled anastomosis in laparoscopic or robotic low anterior resection for rectal cancer: protocol for a multicentre randomised controlled trial
Comparison of oral enalapril-hydrochlorothiazide and oral nifedipine in treating postpartum hypertension: An open label randomised controlled trial
Normoproteic Plant-Dominant Protein Diets, Uremic Toxins, and Gut Microbiota in Patients With Advanced CKD: A Randomized Controlled Trial
Primary thromboprophylaxis in patients with malignancy and central venous catheters: TRIM-Line randomized controlled trial - Design and rationale
Beacon lights path to FDA approval with pivotal trial win for rare vision loss gene therapy
Factor IX Padua AAV gene therapy in adolescents with hemophilia B: a phase 1 trial
Preclinical and clinical investigation of VES001, an oral small molecule sortilin receptor inhibitor for the treatment of frontotemporal dementia: a first-in-human randomized placebo-controlled phase 1 trial
Beyond clinical endpoints: Rethinking ALS drug development through disease biology
A bispecific CD3×CD19 antibody for systemic lupus erythematosus: a phase 1 trial
After decades of trial failures in chemotherapy-linked neuropathy, psilocybin shows promise in preventing it in mice
Tufts model estimates 82x ROI and up to $21 million in value from Medable AI agent
REGULATORY
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Opinion: Former FDA commissioners: Heidi Overton has an opportunity to strengthen the FDA
Cordis’ sirolimus drug-coated balloon earns FDA approval as a breakthrough device
Beacon lights path to FDA approval with pivotal trial win for rare vision loss gene therapy
Eli Lilly escalates oral SERD battle with FDA approval for Inluriyo, Verzenio combo
FDA approves Ultragenyx’s gene therapy Fayuvi for rare neurodegenerative disorder
The oral exposure challenge in PROTACs: What drug developers need to solve early
DRUG DISCOVERY
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Boehringer, Envisagenics sign $1B multi-target oncology collaboration
FuTCM-PDD: a multi-level information fusion framework integrating KAN modeling and AutoML for phenotype-based drug discovery from Traditional Chinese Medicine
Virtual screening of Kv1.3 inhibitors and investigation of their molecular mechanisms in alleviating alcoholic liver injury in mice
Discovery of natural product antagonists for the P2X7 receptor through virtual screening
Researchers create virtual cells to accelerate drug discovery efforts
Editorial - Re-emergence of covalent modulation in drug discovery
Identification of potential SARS-CoV-2 Mpro inhibitors from a Thai natural product database via interaction fingerprint-based virtual screening
Incentivizing challenging drug discovery: from reducing failure to quantifying uncertainty
Dark proteome and emerging technologies for functional characterization and drug discovery
Artificial intelligence-assisted lead optimization in drug discovery: bridging computational advances and translational challenges
Control theory of aging and longevity for gerotherapeutic drug discovery: state space, vector fields, modalities, safety, and the minimum safe cost of functional restoration
Pathway-driven target prioritisation in drug discovery
From virtual screening to cell-based assays: structure-guided identification of EGFR-targeting perimidine derivatives with anticancer activity
Design, synthesis, and structure-activity relationships of ω-aryloxy-α-hydroxyalkanoates as selective lateral root inhibitors
Revisiting multicomponent Doebner and Povarov quinoline synthesis for modern-day drug-discovery
Insilico Medicine launches AI initiative to develop longevity vaccines
Thieno[2,3-d]pyrimidine scaffold optimization for synergistic c-Met/STAT3 blockade: Synthesis, structure-activity relationships, in vitro potency, and apoptotic pathways in colorectal cancer
Hyperaccumulator-derived biochar catalysts for persulfate activation: Structure-activity relationships and regulation strategies
TRPM8 virtual screening: the essential role of target-specific, inactive-enriched machine-learning scoring functions
Nucleic acid aptamers: new methods for selection, target validation, molecular diagnostics and therapeutics
INDUSTRY
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Novartis secures new radioligand in $900M deal as competition strengthens
'Europe does not value what you do': 9 pharmas make urgent call for bloc to beef up innovation muscle
Travere CEO Eric Dube to step down after transforming the rare disease biotech
Otsuka heads to FDA as Ionis-partnered ALS drug hits primary phase 3 endpoint
A hidden tradeoff in Trump’s drug pricing deals
Radiopharmaceutical Dealmaking Continues With Telix’s $1.65B ITM Acquisition
New MFN deal details reignite concerns that Trump's pricing policy favors pharma
Telix buys ITM in bid to create a ‘radiopharmaceutical powerhouse’
How J&J paved the way for Compass’ coming psychedelic drug launch
Analysts ‘extremely bullish’ as Telix beams into Novartis’ territory with $1.6B ITM acquisition
Telix to acquire ITM in deal worth up to $2.35bn
Retension and Lilly-backed TRex Bio both set out plans to join biotech IPO stampede
Cue chalks up phase 2 hives win for Xolair challenger
Beacon lights path to FDA approval with pivotal trial win for rare vision loss gene therapy
Refreshed Novo corrals 3 new early-stage obesity drugs from Kallyope
Inside the growing world of biopharma prediction markets
The best biotech conversations you missed this summer
How Learning Systems Move Pharma Marketing Beyond the Box Score
Oncology biotech news: key moves to watch in September 2026
New non-opioid pain medication: How is the biotech industry fighting pain after the opioid crisis?
RESEARCH
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Stanford scientists discover the human brain may actually be two separate organs
Scientists discover metabolite fueling aggressive brain tumor growth
Scientists discover cells that cheat death and rebuild damaged tissue
Hidden “immune organ” in the skull may help fight brain cancer
Does Exercise Improve Cancer Survival?
Scientists find how “zombie” cells fuel inflammation as we age
Scientists discover the human heart can regrow muscle after a heart attack
Scientists find a human-only gene that may help explain our brainpower
High blood sugar may help cancer cells hide from the immune system
Scientists find the “Achilles’ heel” of deadly gut bacteria
Scientists discover hidden “footprints of death” that may help viruses spread
The tea in your kombucha changes more than just the taste
Scientists discover why ozempic may not work for some people
Scientists discover simple way to relieve arthritis pain without pills or surgery
MIT scientists discover amino acid that helps the gut heal itself
Scientists discover vitamin B2 may help cancer cells survive
Your “um” and pauses could reveal early dementia risk
Scientists discover a weak spot shared by polio and common cold viruses
Scientists find natural compounds that hit COVID-19 from every angle
Scientists discover why Ozempic works better for some people
TECHNOLOGY
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CRISPR & GENE EDITING
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Author Correction: Tracking-seq: a universal off-target detection approach for CRISPR–Cas genome editing
p38 MAPK inhibition safeguards genome integrity during gene editing of hematopoietic stem and progenitor cells
CRISPR-Cas immune repertoires as an ecological record of bacterial interactions with mobile genetic elements in the human gut
CRISPR activation of endogenous PKD1 increases polycystin-1 levels and suppresses cellular features of ADPKD
Hypertriglyceridemia and atherosclerosis in Apolipoprotein A5 mutant rabbits generated using CRISPR/Cas9
Advancing the sterile insect technique for the New World screwworm fly: the case for CRISPR-engineered genetic sexing strains
Technical limitations of CRISPR-Cas9 genome editing in bacteria: challenges and future directions
Multiplex CRISPR/Cas12a editing of ROC5, GS3, GW2, and LARGE2 reveals effects on yield-related traits in rice cultivar Kasalath
Beyond gene editing: the age of chromosome-scale genome engineering
CRISPR and Gene Editing Approaches in Prostate Cancer: Clinical Applications and Therapeutic Potential
T2T genome assembly and CRISPR/Cas9 editing of Medicago lupulina
Development of CRISPR_SCD001, an Autologous Hematopoietic Stem Cell Gene Therapy for Sickle Cell Disease after CRISPR-Cas9 Mediated Correction
Adenine base editing slows neurodegeneration in hereditary motor neuron disease
Graft Biology in the CRISPR Era: From Tissue Fusion to Genome Compatibility
CRISPR beyond biology: building a sustainable innovation system
CD73 disruption with tumor-specific CRISPR/Cas9 nanoparticles reduces adenosine-mediated immunosuppression and amplifies response to chemotherapy
MtvS1 and MtvS2 Interact with RNA polymerase to regulate the Francisella type V-A CRISPR-Cas system
Genetic transformation and CRISPR/Cas12a-mediated gene editing of European beech (Fagus sylvatica L.) employing a transient protoplast system
Single-cell and in vivo profiling reveal heterogeneous and organ-specific CRISPR-Cas9 off-target and translocation outcomes
Transposon end recognition and excision mechanisms of type I-F CRISPR-associated transposases
CELL & GENE THERAPY
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Made Scientific acquires cell therapy facility in Pennsylvania, US
Multiomics analysis of keratinocyte differentiation identifies secreted markers for non-destructives cell therapy in-process controls
Advancing Cell Therapy for Cardiovascular Disease
Mesenchymal Stem Cell Therapy for Ischemic Stroke: Bridging Clinical Evidence and Translational Challenges
Safety and Efficacy of Mature Cultured Corneal Endothelial Cell Therapy (Vyznova) in Eyes With Declining Long-term Efficacy After Prototype Cell Transplantation
A Phase I/II Trial of Anti-CD22/CD19 CAR-T Cell Therapy, CART2219.1, in Adult and Pediatric Relapsed/Refractory B-ALL
IL-21 boosts T cell-therapy efficacy for solid tumors by enhancing mitochondrial Ca2+-mediated motility of effector CD8+ T cells
TSPAN32 enhances CAR-T cell potency by assembling IL-2 receptor complex and amplifying its intracellular signal transduction
In vivo CAR‑T cell therapy: mechanisms, clinical advances and optimization strategies
Practical Considerations for Gene and Cell Therapy Delivery in Temporal Lobe Epilepsy and Other Neurological Disorders
Gene regulatory elements determine efficacy of BCMA-targeted CAR-T cell products
CD28-ICOS costimulation enhances the therapeutic efficacy of L1CAM-targeted CAR-T cells against ovarian and gastric cancers
Submacular Hemorrhage Secondary to Cytomegalovirus Retinitis after Chimeric Antigen Receptor T-Cell Therapy
RHOA Deletion Downregulates CD19 and Promotes Dysfunctional Immune Microenvironments in CAR-T Resistant Large B-cell Lymphomas
Armouring GPC3 CAR T cells for hepatocellular carcinoma: how much is enough and what comes next?
Regeneration and Replacement of the Corneal Endothelium: Advances in Cell Therapy, Tissue Engineering, Molecular and Pharmacologic Strategies
Rethinking Platelet Hemovigilance After CAR-T Therapy
Genomic and transcriptomic quality control for an autologous iPSC-derived cell therapy for Parkinson's disease
Association between CAR T-cell persistence and improved response to salvage radiotherapy in patients with DLBCL
A cancer therapy put severe rheumatoid arthritis into remission
BIOPRINTING
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Cell-laden 3D bioprinted hydrogels for wound healing: cellular mechanism, bioprinting determinants and translational perspectives
A Hybrid Bioprinting-Microfabrication Approach to Controllable Multitype Spheroid Arrays for Modeling Tumor Heterogeneity
The Tissue Engineering Grail: Seamless Biofabrication of Scaffold-Free Hollow Constructs
Decellularized extracellular matrix bioinks through a polymer engineering lens: tissue-source-dependent macromolecular architecture, crosslinking chemistry, rheological behavior, and 3D bioprinting performance
4D bioprinting in advanced cancer model: technologies, drug delivery, and translational challenges
Bioprinted dentin-pulp platform with decoupled mechanics promotes mineralization and vessel-like structures' formation in confined 3D microenvironments
In situ bioprinting of patterned prevascular tissue using cell-only bioinks and high-density stem cell-laden alginate microgel bioinks for vascularized bone tissue regeneration
Exploring a cold-gelled whey protein-based ink for applications in cultured meat 3D bioprinting
Porcelain-clay-inspired microsphere hydrogel bioink facilitates bone regeneration via immune-osteogenic regulation
3D Bioprinting Approaches for Dental Pulp Regeneration: A Scoping Review
3D bioprinting of stromal vascular fraction enriched with MXenes for enhanced intestinal regeneration
Inkjet biofabrication of electroactive rGO/growth-factor micropatterns on electrospun PLCL for guided neural cell responses
Leveraging Navier-Stokes Principles to Engineer Perfusable Bioorgans: A Physics-Guided Paradigm for Bioprinting
Characterization and in vitro evaluation of double cross-linked PVA/chitosan-alginate biocomposite scaffolds coated with turmeric extract produced by 3D bioprinting
Development of a 3D-bioprinted tumour-on-chip with tunable hydrogel properties for monitoring colorectal cancer cell migration and invasion
Magnetically Driven Biofabrication for Tissue Engineering: From Nanoparticle Design to Mag-ATMP Translation
Advancing European standards and regulations for 3D bioprinting
Three-Dimensional Bioprinting in Reconstructive Plastic Surgery: A Comprehensive Review
Next-generation hydrogels and strategies to recreate 3D tumour microenvironments for osteosarcoma: from bioprinting to therapeutic testing
3D Bioprinted Alginate-Gelatin-Collagen Based Hydrogels Laden With Fibroblast and Keratinocyte Cells Show Potential for Regeneration of Injured Skin
PRECISION MEDICINE
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Precision oncology in GI-cancers: Mechanisms of action, indications and ongoing strategies to overcome primary and secondary resistance
Why Exercise Does Not Work Equally Well for Everyone: Life-Course Conditions and the Limits of Precision Medicine
Epigenetic deregulation in adult gliomas: A key driver of molecular heterogeneity and precision oncology
Precision medicine for pediatric gliomas
Rethinking fear of cancer recurrence/progression in the era of precision medicine: is it time to consider separating?
Fibrosis: Bridging fundamental mechanisms to precision medicine via advanced therapeutics
Organoids Serve as Viable In Vitro Model for Functional Precision Medicine for Mesonephric-Like Adenocarcinoma of the Ovary
Precision medicine in pediatric sepsis-associated acute kidney injury: when systemic heterogeneity meets organ-level heterogeneity
Innovative positioning of respiratory allergen immunotherapy: a focus on precision medicine
Precision Medicine for Somatic Mutation-Driven Vascular Anomalies
Toward precision psychiatry: integrating pharmacogenomics and multimodal clinical data for personalized antidepressant response prediction
Towards precision medicine: Application of the structural causal model in psychiatry
Evolutionary genomics, tumor dynamics, and mathematical modeling of cancer progression: Implications for precision oncology
TISON: A Web Server for Omics-driven Integrative Cancer Modeling & Simulations towards Personalized Medicine
Tumor-homing peptides in precision oncology
Identifying General Practitioners, Nurses, and Pharmacists Training Needs in Precision Medicine: A Survey Study
Personalized medicine at the push of a button: printer design and implementation of SSE pharma printing in a hospital pharmacy
Epigenetic Insights and Exosome-Based Therapeutics for Insomnia: Bridging Sleep Biology and Precision Medicine
Folate-modified chitosan nanocarriers in precision oncology: molecular engineering, targeted drug delivery, and clinical perspectives
Looking to the Future: How Will Personalised Medicine Impact Facial Plastic Surgery
STEM CELLS
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Stem cells reverse stroke damage and restore movement in mice
Pyruvate metabolism modulates cell fates in naïve human pluripotent stem cell culture and blastoid formation
Naive T cell-depleted hematopoietic stem cell transplantation to minimize immunosuppression after solid organ transplantation: case report
Mesenchymal Stem Cell Therapy for Ischemic Stroke: Bridging Clinical Evidence and Translational Challenges
What can we learn on ALS pathophysiology from iPSC-derived motor neurons harbouring TARBDP mutations: a systematic review
Zfp462 Regulates the Pluripotency of Embryonic Stem Cells by Cooperating with the Core Transcriptional Network
A human iPSC-based perfusable and membrane-free neurovascular unit-on-chip connecting brain organoids to the blood-brain barrier
Development-inspired approach for the derivation of functional and transplantable salivary gland organoids from human pluripotent stem cells
Generation of an induced pluripotent stem cell line from a long QT syndrome type 1 patient carrying the KCNQ1 c.343G > A p.(E115K) variant
Generation of an induced pluripotent stem cell line, JHUi010-A, from an arrhythmogenic cardiomyopathy patient harboring pathogenic DSG2 variant c.2358delA
Generation of two human induced pluripotent stem cell lines from patients with hypokalemic periodic paralysis
Genomic and transcriptomic quality control for an autologous iPSC-derived cell therapy for Parkinson's disease
Hyperbaric Oxygen Treatment Enhances Definitive Endoderm Differentiation and Hepatic Maturation of Human-Induced Pluripotent Stem Cells in Association with mTORC2-Dependent AKT Phosphorylation
Kit-based remote collection and isolation of human reprogrammable somatic cells for generation of induced pluripotent stem cells and cerebral organoids
Generation of the induced pluripotent stem cell line SHUTCMi001-A from a patient with double primary lung and colon cancers
Kit-based remote collection and isolation of human reprogrammable somatic cells for generation of induced pluripotent stem cells and cerebral organoids
Clinical safety and preliminary efficacy of allogeneic human induced pluripotent stem cell-derived exosomes in patients with acute ischaemic stroke: protocol of a phase I/II clinical trial in China
Ten-Year Survival of First-in-Human Autologous Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Sheet Transplantation
Self-amplifying RNA enables rapid, durable, integration-free programming of hiPSCs
A common vape flavoring may disrupt early embryo development
NEW APPROACH METHODS
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Patient-Derived 3D Cell Models as New Approach Methodologies: Applications, Advances, and Challenges for Increased-Throughput Assays
Advancing Regulatory Adoption of New Approach Methodologies
New approach methodologies in neurotherapeutics development
Finding a place for new approach methodologies (NAMs) in biomedical research
Applications of in vitro new approach methodologies (NAMs) in drug development: A scoping analysis of titles of nonclinical study reports submitted to the FDA
Evaluating local neurotoxicity potential of extractables and leachables: Comparison of in vivo and in vitro data and need for new approach methods
Expanded evaluation of a robust on-line sample cleanup-LC-MS platform suited for new approach methodologies (NAM)
Educational and training needs of regulatory professionals for non-animal methodologies: Insights from a survey
Independent testing infrastructure for new approach methodologies: the UC Davis NAMs testing center
Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science
The Current Status of the 3Rs Principles in Animal Use in Bosnia and Herzegovina: Overview and Future Perspectives
Histotechnology at the crossroads of innovation: why morphology is the foundation of New Approach Methodologies
Integrating new approach methodologies and artificial intelligence to advance central nervous system toxicity prediction: lessons from preclinical and clinical case studies
Laboratory animal science cannot afford sex bias: Aligning the 3Rs with sex-inclusive research
Toxicologic Pathology Forum: ESTP/STP Working Group Opinion on the Evolving Landscape of New Approach Methodologies in Drug and Chemical Safety Development
State of the industry: integration of 3Rs principles and new approach methodologies in non-clinical product development through fit-for-purpose
Current and emerging new approach & methodologies for skin hazard assessment
From "wish-list" to successful delivery: Opportunities for multidisciplinary and multisectoral engagement in implementation of strategies to phase out animal testing
Beyond monolayers: a comparative analysis of 2D cell cultures and 3D in vitro models as new approach methodologies
A proposed evaluation of new approach methodologies for dermal toxicity assessment of botanicals
FUNDING & VC
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Amgen reports a Phase 3 win with Sjögren’s drug candidate
Lexeo takes up the Mantle in $8M acquisition for Friedreich ataxia assets
Teal Health raises $22M ahead of expected surge in demand with new coverage mandate
Retension and Lilly-backed TRex Bio both set out plans to join biotech IPO stampede
Oncology biotech news: key moves to watch in September 2026
The 50 best-funded biotech companies of 2026
IMMUNOTHERAPY
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Study identifies B cells as drivers of immunotherapy-related colitis
Celldex monoclonal antibody rebounds with pair of phase 3 wins for chronic skin condition
p38α orchestrates BRAFV600E-melanoma progression and immunotherapy response via tumor fitness and immune microenvironment modulation
Prediction of pathological complete response to neoadjuvant chemo-immunotherapy in locally advanced lung adenocarcinoma: a multimodal machine learning approach
Long-term ctDNA reassessment in NSCLC immunotherapy responders
Structural basis of laminin mimicry by E. coli CNF1 and its therapeutic potential for cancer immunotherapy
B cells may play a role in triggering immunotherapy-related colitis
Immunotherapy combined with BCG vaccine drastically lowers tuberculosis relapse risk
Author Correction - with Update (U+C): Miniature and versatile genome regulation TnpB-ωRNA toolkits facilitate cancer immunotherapy
Scientists turn probiotic bacteria into tiny drug factories for pancreatic cancer
Gilead and Nucleai probe why target-positive tumors can still resist ADCs
Enhancing iNKT cell immunotherapy through the integration of optimized CAR endodomains and iNKT engagers
Novo Nordisk's ziltivekimab misses Phase 3 primary endpoint
A protein older than blood circulation could transform cancer immunotherapy
CRISPR makes prostate cancer vulnerable to immunotherapy
Tiny silica particles wiped out aggressive prostate cancer in mice
Creatine doesn't just build muscle. It may also help fight cancer
Scientists inject one tumor and watch cancer vanish across the body
A Trojan horse cancer therapy shows stunning results
The hidden reason cancer immunotherapy often fails
MICROBIOME
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Drug–microbiome–host interactions: antimicrobial effects of non-antibiotic compounds
Antifungal therapy improves microbiome dynamics in inflammatory bowel disease
Common medications may change your gut for years
Gut microbiota-derived acetate mitigates Escherichia fergusonii-induced gut dysbiosis exacerbating Klebsiella pneumoniae pulmonary infection in mice
Gut microbiome modulation by Veillonella ratti induces resistance to EAE pathogenesis via microbe-derived metabolites
CARDIOVASCULAR
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Can ARNI Prevent Atrial Fibrillation in Heart Failure with Reduced Ejection Fraction? Real-World Evidence Meets the Randomized Benchmark
Quality Matters after acute myocardial infarction: making LDL-C risk visible, actionable, and accountable
Perioperative Management and Clinical Course of Acromegaly-Related Heart Failure: A Case Report
Multimodality cardiac imaging in advanced heart failure: Diagnosis, risk stratification, and therapeutic guidance
Hypertonic saline and high-dose furosemide in very elderly patients hospitalized for acute heart failure: A real-world cohort study
Determinants of patient delay in seeking care for worsening heart failure symptoms in out-of-hospital settings: protocol for a systematic review and meta-analysis
Congestive heart failure and other cardiac adverse events after intravitreal anti-VEGF therapy: a systematic review and meta-analysis
Ketone metabolism in heart failure with preserved ejection fraction: fuel, signaling, and therapeutic opportunities
Lipid Signaling and Foam Cell Formation in Atherosclerosis and Spinal Cord Injury
Hypertriglyceridemia and atherosclerosis in Apolipoprotein A5 mutant rabbits generated using CRISPR/Cas9
Contemporary lipid management and achievement of LDL-C targets after acute myocardial infarction in Japan: Insights from the K-ACTIVE registry
Association of in-Hospital Mineralocorticoid Receptor Antagonist Initiation with Outcomes According to guideline-defined eGFR and potassium eligibility in patients with heart failure
Influence of donor-transmitted coronary artery disease on the progression of coronary vasculopathy after heart transplantation
Letter by Dai et al Regarding Article, "Coramitug, a Humanized Monoclonal Antibody for the Treatment of Transthyretin Amyloid Cardiomyopathy: A Phase 2, Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial"
Response by Oldgren and Wallentin to Letter Regarding Article, "Biomarker-Based ABC-AF Risk Scores for Personalized Treatment to Reduce Stroke or Death in Atrial Fibrillation: A Registry-Based, Multicenter, Randomized, Controlled Study"
Response by Maurer and Fontana to Letter Regarding Article, "Coramitug, a Humanized Monoclonal Antibody for the Treatment of Transthyretin Amyloid Cardiomyopathy: A Phase 2, Randomized, Multicenter, Double-Blind, Placebo-Controlled Trial"
Letter by Zhao et al Regarding Article, "Biomarker-Based ABC-AF Risk Scores for Personalized Treatment to Reduce Stroke or Death in Atrial Fibrillation: A Registry-Based, Multicenter, Randomized, Controlled Study"
Single-cell RNA-seq and machine learning identify HMGN2 as a lactylation-associated hub gene in heart failure
Quantitative [13N]ammonia/[18F]FDG PET/CT predicts left ventricular functional recovery after CABG in ischemic cardiomyopathy: An exploratory study
Powerful cholesterol drug cuts heart attack risk by 31%
ONCOLOGY
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City of Hope develops adaptive plug-and-play CAR T technology to attack tumors
Harnessing nanomedicine for breast cancer therapy through the immunomodulatory activity of BCc1
Increased myocardial [64Cu]Cu-DOTATATE uptake is associated with subsequent cancer therapy-related cardiac dysfunction in rats
Bayer offloads cancer drug Stivarga to Grünenthal for up to $431M as new competition looms
Circulating and spatial immune biomarkers of response to neoadjuvant chemotherapy and nivolumab in ER + /HER2- breast cancer: analysis of the phase II GIADA trial
Evaluating a PBMT–pilocarpine combination to improve salivary gland function during radiochemotherapy in head and neck cancer: an exploratory randomized trial
Toxicity Attribution During Enfortumab Vedotin Plus Pembrolizumab Therapy in Urothelial Carcinoma: A Practical Framework
Commercial large language models for oral cavity cancer staging using descriptive pre-treatment MRI reports: ready for standalone use in clinical practice?
The Interplay Between Thyroid Cancer and Cardiovascular Disease: Shared Mechanisms, Treatment Implications, and Survivorship Perspectives
WCLC 2026: The lung cancer drug development readouts that caught our eye
How a team of AIs discovered a promising lung-cancer drug
Less Overdiagnosis In Breast Cancer Screening Than Thought, Study Finds
Cancer treatment alters mutant selection in normal esophagus
AI model predicts which breast-cancer drugs work best
After decades of trial failures in chemotherapy-linked neuropathy, psilocybin shows promise in preventing it in mice
Scientists find a new weakness in treatment-resistant prostate cancer
CD73 disruption with tumor-specific CRISPR/Cas9 nanoparticles reduces adenosine-mediated immunosuppression and amplifies response to chemotherapy
Scientists find breast cancer cells hiding behind protective “shields”
A cancer therapy put severe rheumatoid arthritis into remission
A binding-to-release strategy for targeted anticancer drug delivery
NEUROSCIENCE
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Otsuka heads to FDA as Ionis-partnered ALS drug hits primary phase 3 endpoint
Quantitative Assessment of Facial Expression Asymmetry in Parkinson's Disease
Convergent Astrocytic Failure in Parkinson's Disease: A System-Level Model of Pathogenesis and Treatment
Tinosinenside A ameliorates Alzheimer's disease-related pathology in APP/PS1 mice, accompanied by reduced neuroinflammation and altered microglial phenotype-associated marker expression
A multi-omics insight into the sex-specific burden of tobacco-associated neurodegeneration: trends, projections, and mechanistic clues from the TH gene
Identification of Gene Signatures and Molecular Mechanisms Underlying the Comorbidity of Alzheimer's Disease and Crohn's Disease Using Machine Learning
Striatal Dopaminergic Reserve Shapes the Longitudinal Impact of Peripheral Immune Activation on Motor Progression in Parkinson's Disease
Ursodeoxycholic Acid and Parkinson's Disease Risk: An Emulated Target Trial in UK Electronic Health Records
Nuclear Medicine-Based Diagnosis and Therapeutic Strategies for Neurodegenerative Diseases: Clinical Progress
Mental Health, Neurodegenerative, and Cardiovascular Health of Korean Kidney Transplant Recipients in Single-Person Households
T1 mapping in Alzheimer's disease: a quantitative MRI study with amyloid-PET correlation
Phytogenic Nanoparticles for Parkinson's Disease Therapy: Mechanistic Insights, Brain-Targeted Delivery and Neuroprotective Potential
Real-world neuropsychiatric safety profile of foslevodopa/foscarbidopa infusion in advanced Parkinson's disease
Healthy rural living: a misplaced optimism? : District-level agricultural index and Parkinson's disease risk in Austria
Cognition endpoints for Parkinson's disease: A roadmap for developing patient-focused assessment tools to accelerate drug development
Effects of deep brain stimulation on functional autonomy and quality of life in Parkinson's disease: A systematic review and meta-analysis
CD8+ T cells in synucleinopathies: differential immune mechanisms in Parkinson's disease and multiple system atrophy
Lysosomal Expression Profile in Plasma Associates with Disease Severity in Parkinson's Disease
Scientists find a new layer of Alzheimer’s hidden in the genome
Beyond clinical endpoints: Rethinking ALS drug development through disease biology
INFECTIOUS DISEASE
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LNP-formulated dbDNA™ vaccines elicit durable humoral and cellular immunity with distinct kinetics to mRNA in non-human primates
Appropriateness of antibiotic selection at emergency department discharge and risk of 30-day adverse events in patients with acute exacerbation of COPD
Evaluation of suspected delayed-type allergy to beta-lactam antibiotics: a 6-year retrospective single center experience
Single-Atom O/S/Se Substitution at the Glycosidic Linkage in Glycopeptide Cancer Vaccines Reveals Divergent Performance
Clinical Effectiveness of the Recombinant Zoster Vaccine in Kidney Transplant Recipients-But Wait…There's More!
Edible Fish as a Source of Klebsiella pneumoniae: Incidence, Virulence, Biofilm Formation, Antimicrobial Resistance and Control Strategies
International epidemiology of antimicrobial resistance in people living with chronic lung infection
Intradermal hepatitis B vaccination with or without Imiquimod in cirrhosis after prior vaccine nonresponse: A Randomised Trial
Changes in Inhaled Antibiotic Associated lung function outcomes in the CFTR-Modulator Era
Increasing the immunogenicity of a salmon louse immune dampening protein for DNA vaccine application in Atlantic salmon
A self-adjuvant trivalent T4 bacteriophage nanoparticle vaccine induces broad protective immunity against Orthoebolaviruses
Epidemiology and Antimicrobial Resistance Trends of Invasive Bacterial Pathogens in The Gambia: A Retrospective analysis, 2019-2024
Increased Risk of Periprosthetic Joint Infection Following Aseptic Revision Hip and Knee Arthroplasty With the Use of Non-Cefazolin Alternative Antibiotics
Antibiotic Prophylaxis for Dermatologic Surgery. Part 1: Indications, Guidelines, and Special Populations
A Decade-Long Nationwide Surveillance of Antimicrobial Resistance in Coagulase-Negative Staphylococci in China (2014-2023) and Characterization of a Rare Teicoplanin-Resistant Staphylococcus haemolyticus
Optimal Control of Dengue under Vaccine Heterogeneity: From Dynamical Analysis to Dynamic Strategy Optimization
Bioaccumulation of Three Typical Antibiotics in the Edible Bivalve Tegillarca granosa: Potential Mechanisms and Human Health Implications
Prevalence, Serovar Diversity, and Antimicrobial Resistance Disparities ofSalmonellafrom Retail Pork and Chicken in Yuyao, China, 2019-2025
Early Broad-Spectrum Antibiotic Exposure Is Associated with Increased Relapse after Myeloablative TBI-Based Allogeneic Hematopoietic Cell Transplantation
Highly efficient intranasal H5N1 vaccine based on a safe vesicular stomatitis virus (VSV) vector
LIQUID BIOPSY
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Performance and safety of a multi-cancer early detection test: the PATHFINDER 2 study
Long-term ctDNA reassessment in NSCLC immunotherapy responders
AI blood test finds silent liver disease years before symptoms
A Mechanophenotyping chip for high-throughput detection of metastatic bacteria-infected circulating tumor cells
New blood test shows superior sensitivity in detecting HPV-associated head and neck cancers