Tumor Antigens
CD19
B-cell malignancies (ALL, DLBCL)
Expression: High on B-cells
CD22
Relapsed ALL
Expression: B-cell specific
BCMA
Multiple Myeloma
Expression: Plasma cells
HER2
Breast, Gastric cancer
Expression: Overexpressed tumors
EGFRvIII
Glioblastoma
Expression: Tumor-specific variant
Mesothelin
Mesothelioma, Ovarian
Expression: Solid tumors
CAR Generation
CAR Construct
scFv (Antigen Binding)
Not designed
Hinge Region
CD8α
Transmembrane
CD8α TM
Costimulatory
4-1BB
Signaling Domain
CD3ζ
Performance Metrics
Transduction Efficiency
0%
Cell Expansion
1x
Cytotoxicity
0%
Persistence (Days)
0
Tumor Reduction
0%