Live News Categories
ORGAN-ON-CHIP
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Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy
Exploring the Translation of Organ-on-a-Chip Technology for Human-Relevant Diagnostic Biomarkers
Microfluidic engineering of polymer-based drug delivery systems: From particle synthesis to organ-on-a-chip validation and application
New Dimensions in Diabetic Kidney Disease Research: Advanced Organoids and Organs-on-a-Chip
Organ-on-a-Chip Technology: Advances in Modeling Inflammation, Neurovascularization and Nociception in Human Intervertebral Disc Degeneration
Microphysiological immune-on-chip systems: engineering human immunity for precision immunotherapy, vaccine development, and autoimmune disease modelling
5 perspectives on translating microphysiological systems from concept to application
Organ-on-chip bridging musculoskeletal disease modeling and precision therapeutic discovery
Organoids and organ-on-a-chip platforms for advancing oligonucleotide drug development
A human iPSC-derived kidney-liver organ-on-a-chip platform for modeling inter-organ crosstalk
Artificial intelligence across organ-on-a-chip workflows: current implementations and future approaches
A cleanroom-free membrane-integrated organ-on-a-chip platform for rapid intestinal tissue formation
An LCD 3D-printed microphysiological system with deflectable extracellular matrix thin films
Modeling sympathetic neuro-cardiac interactions in a hiPSC-based microphysiological system
From Organoids to Organ-on-Chip: Advancing Human-Relevant Models for Viral Pathogenesis and Antiviral Drug Discovery
The synergy of artificial intelligence and organ-on-a-chip: building a next-generation intelligent engine for drug development
Making the Case for Organ-on-Chip Platforms in Long-Acting Therapeutics Development
Human-Relevant Microphysiological Systems: Evidence for Defined Contexts of Use
EnView: a tunable microphysiological platform with human crypt-scale topography and independent apical-basal flow for long-term culture and imaging of colonic epithelial monolayers
Integration of multi-stacked biodegradable PLGA membranes into microfluidic organ-on-a-chip devices for tunable barrier co-culture
ORGANOIDS
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Quantitative imaging of dynamic processes in intestinal organoids
A provisional and evolving framework for standardizing cartilage organoid construction: toward consistency, reproducibility, and clinical translation
Endodermal Organoids Along Two Axes: Single-Organ Fidelity, Inter-Organ Reconstruction, and the Unbuilt Gut-Lung Frontier
Midbrain organoids as next-generation models for Parkinson's disease: From pathogenesis to therapeutic discovery
Bupleuri Radix- Aurantii Fructus Immaturus pair attenuates metabolic dysfunction-associated fatty liver disease in association with modulation of PI3K/Akt-GSK3β/FoxO1 pathway: Evidence from multi-model validation including human iPSC-derived liver organoids
Elucidating the role of DEAF1 in neurodevelopment and shared molecular pathways in high-risk autism genes using cortical organoids
Multicellular rosette formation guides epithelial tissue assembly in pancreatic ductal adenocarcinoma cell organoids
Evaluation of anti-tumor drugs by simulating physiological absorption and metabolism with a multi-organoid system
Chemical induction and reversal of photoreceptor dystrophy in retinal organoids
Multicellular human cardiac organoids with real-time calcium imaging enable functional modeling of heart failure and myocardial infarction
Real-time monitoring of CAR T cell dynamics in tumor patient-derived organoids using the OrganoIDNet algorithm
Reassembly of human kidney organoids after dissociation
Photonic crystal barcode microfluidic chip for smart screening of lactogenic Chinese herbs using human mammary organoids
Kidney-on-Chip and Organoid Models: Harnessing Mechanical Forces for Translational Kidney Biology
Human iPSC-derived vascularized organoids: strategy-based insights from 2D endothelial cells to 3D blood vessel organoids
Construction of Vascularized Intestinal Organoids Based on Scaffolds, Hydrogels, and 3D Printing Technologies and Their Applications in Drug Delivery
Fatty acid shifts the cellular composition of small intestinal organoids towards a secretory cell lineage
A closed-loop paradigm for precision oncology: Integrating dynamic monitoring, organoid models, and explainable AI
Engineered Mesenchymal Stem Cells Expressing CD::UPRT and TRAIL Exhibit Potent Anti-Tumor Effects in Glioblastoma Patient-Derived Organoids
Patient-derived organoids as predictor of clinical response in ovarian cancer: a systematic review
DIGITAL TWINS
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Investigation of in vivo silk scaffold degradation by decoupling tissue ingrowth using a Gaussian process regression-driven digital twin framework
FedEC-Dia: Explanation-Calibrated Federated Learning for Patient-Level Diabetes Digital Twin Risk Prediction Under Non-IID Healthcare Data
A cellular Digital Twin framework for predictive and mechanistic modeling of drug responses in precision medicine
From self-quantification to predictive ageing: Digital twins as a framework for healthy ageing and longevity
Reframing chronic hepatitis B care through digital twin modelling
A Novel Tool to Create Digital Twin Temporal Bone Models for Virtual and 3D-Printing: Proof-of-Concept and Evaluation
CXCR4-centred signalling network rewiring distinguishes primary and metastatic prostate cancer: A systems-level digital twin framework
Structural requirements for intelligent clinical digital twins in feedback-driven care
Digital twin-enabled toxicology: Current applications, opportunities, and future directions
Digital twins are funhouse mirrors: Five systematic distortions
Real-Time Physiological Fatigue Prediction for Human-Robot Collaborative Manufacturing Using Wearable Sensor Fusion and Hybrid Deep Learning: An In Silico Digital Twin Study
Hybrid Digital Twin Framework for Personalized Diabetes Management Using Mathematical Modelling and Machine Learning
A Real-Time Digital Twin for Human Cardiovascular Applications
Integration of biological avatars and digital twins for "ex vivo clinical trials"
Sex-specific assumptions underlie cardiovascular digital twin technologies: A narrative review
Practicing pediatric interviews with parents through conversational AI-based virtual patients: an observational study in Spanish undergraduate medical education
Virtual-patient nonlinear mixed-effects modelling for data-driven optimisation of single-time-point dosimetry: a proof-of-concept study in [177Lu]Lu-PSMA-617 therapy
Atrial digital twins reproducing clinical biomarkers of intracardiac electrograms
Digital twin technology for HIV patient virtual modeling: a novel approach to treatment optimization
ReplayBG-Web: A Novel Web Interface to Ease the Creation and Use of Digital Twins for Type 1 Diabetes
AI & MACHINE LEARNING
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[Advances in medical image-based artificial intelligence for precision diagnosis and treatment of head and neck tumors]
[Advances in the application of artificial intelligence in the diagnosis and treatment of head and neck tumors]
[Multimodal artificial intelligence driving precision diagnosis and treatment of otolaryngologic diseases: key challenges and future directions]
RCoxNet: A Deep Learning Framework Integrating Random Walk with Restart, Mutation, and Clinical Data for Cancer Survival Prediction
Applications of Machine Learning in Noninvasive Anemia Diagnosis: A Systematic Review Based on Cross-Industry Standard Process for Data Mining
The Use of Ambient Dictation Artificial Intelligence in Clinical Spaces in Surgery: A Scoping Review
From Promise to Practice: Artificial Intelligence in Psychiatry and the Path to Clinical Impact
Evaluating artificial intelligence in the diagnosis of hip fractures: an analysis of sensitivity, specificity, positive and negative predictive values, and accuracy
Integrated single-cell transcriptomics, Mendelian randomization, and machine learning identify CEBPZ as an immune-related biomarker in oral lichen planus
Converging endoscopic techniques and artificial intelligence for diagnosis and risk stratification of pancreatic cystic neoplasms
Optimizing deep learning-enhanced opportunistic osteoporosis screening from chest X-rays in Australia: Impact of follow-up and treatment adherence on clinical and economic outcomes
Parkinson's disease diagnosis using machine learning and multimodal biomarkers: A systematic review
Artificial Intelligence and the Future of the Clinical Workforce
Accelerating HDAC8 inhibitor discovery through deep learning, cheminformatics, docking, and molecular dynamics simulations
Artificial Intelligence as an Assistive Tool in Breast Cancer Screening and Diagnosis in the Digital Era
Current state of research and future developments of artificial intelligence in pain diagnosis and treatment
Artificial Intelligence-Related Voice and Speech Biomarkers of Alzheimer's Disease: A Systematic Review
Deep Learning-based Intelligent Diagnosis of Congenital Uterine Anomalies in 3-D Ultrasound
Future promise, current clinical ambiguity: a systematic review of machine learning algorithm outputs predicting risk of cardiovascular disease
Generative AI-driven drug Rentosertib enters Phase III trial for idiopathic pulmonary fibrosis
CLINICAL TRIALS
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Factor IX Padua AAV gene therapy in adolescents with hemophilia B: a phase 1 trial
Sling reels in $123M series C to fund oral Tepezza rival through phase 3 trial
FDA launches pilot program to speed up sluggish phase 1 trials
Electra targets $342m IPO to fund hyperinflammatory syndrome drug’s pivotal trials
STAT+: Vera kidney drug Trutakna shows strong final results in Phase 3 trial
J&J’s Contineum-partnered depression drug flunks another phase 2 test
Oral KRAS G12D inhibitor GFH375 for previously treated advanced solid tumors with KRASG12D mutations: a phase 1 trial
Comparison of the effects of two sexual counseling models, GES (Good Enough Sex) and PLISSIT (Permission, Limited Information, Specific Suggestions, Intensive Therapy), on sexual dysfunction in postmenopausal women: a randomized controlled trial
Early-stage trajectories of social-occupational functioning and long-term functional outcome prediction in early psychosis: A 12-year follow-up of the randomized controlled trial on extended early intervention
HazAPP: Study protocol of a randomized controlled trial to enhance parental instruction of teens' hazard anticipation skill during the learner phase of licensure
Axoltis misses the mark in phase 2 ALS study, but will persevere with the synthetic peptide
Preclinical and clinical investigation of VES001, an oral small molecule sortilin receptor inhibitor for the treatment of frontotemporal dementia: a first-in-human randomized placebo-controlled phase 1 trial
Budesonide/formoterol fumarate dihydrate versus budesonide with a novel suspension technology for uncontrolled asthma: phase 3 LITHOS study
Home-Based Cardiac Rehabilitation Using a Smart Ring and Telephone Counselling: A Randomized Controlled Trial
Impact of Dual Interleukin-17A and Interleukin-17F Inhibition with Bimekizumab on Inflammatory and Structural Lesions in Axial Spondyloarthritis: MRI and Radiographic Outcomes from the Phase 3 BE MOBILE 1 and 2 Studies and their Open-Label Extension
Increased deaths shadow AstraZeneca, Daiichi’s Enhertu first-line lung cancer data
Generative AI-driven drug Rentosertib enters Phase III trial for idiopathic pulmonary fibrosis
A bispecific CD3×CD19 antibody for systemic lupus erythematosus: a phase 1 trial
After decades of trial failures in chemotherapy-linked neuropathy, psilocybin shows promise in preventing it in mice
Tufts model estimates 82x ROI and up to $21 million in value from Medable AI agent
REGULATORY
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Vera set up for full approval for Trutakna in IgAN with Phase III win
Teclistamab-associated adverse events: a disproportionality analysis of the FDA adverse event reporting system
Adaptations in pacritinib usage for myelofibrosis and thrombocytopenia since FDA approval
Scholar Rock scores long-awaited FDA approval, the first for muscle loss in SMA
Association Between the Number of US Food and Drug Administration-Warned Anesthetic Exposures and Full-Scale Intelligence Quotient at Age 3 Years in Very Preterm Infants
Implications of Potential US FDA Approval of Psychedelics or Psychedelic-Adjacents Such as Ibogaine for Pharmacy in Japan
GSK prepares frontline FDA bid for Jideytro, its first lung cancer drug
Quantitative Aspects of Non-targeted Analysis for Organic Extractables/Leachables; Insights Secured by Considering the FDA CLAP List Compounds
Key Contamination Control Trends Identified in Recent FDA Warning Letters
Four decades of History & Evolution of Clinical Pharmacology at US Food and Drug Administration (FDA)- Part I: Product Quality
Drugs associated with retroperitoneal fibrosis: assessment of the 1969-2025 Food and Drug Administration (FDA) pharmacovigilance database
Guidance for antidepressant use during pregnancy: A commentary in response to the 2025 FDA panel
Upcoming FDA approval decisions in Q4 2026
Applications of in vitro new approach methodologies (NAMs) in drug development: A scoping analysis of titles of nonclinical study reports submitted to the FDA
(Neo)adjuvant approvals for solid tumors by the US Food and Drug Administration 2010-2023
Safety evaluation of zuranolone in the management of postpartum depression: A real-world pharmacovigilance study using the FDA adverse event reporting system (FAERS)
Networked Radiology Imaging and Treatment Planning Systems and FDA Cybersecurity Regulation: A Difference-in-Differences Analysis of 510(k) Clearance Delays
Analysis of marketing authorizations, withdrawals, and refusals by the European Medicines Agency (EMA): trends in approval procedures 1995-2025
The Application of FDA Patient-Focused Drug Development Guidance in Rare Patient Populations: Innovation and Flexibility
The oral exposure challenge in PROTACs: What drug developers need to solve early
DRUG DISCOVERY
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Insilico Medicine launches AI initiative to develop longevity vaccines
From implicit prioritization to auditable decisions in natural product drug discovery
New phenolic derivatives and bioactive constituents from Castanopsis lamontii Hance: enzyme inhibitory activities and structure-activity insights
Dual screen for gut metabolites suppressing enterobacterial growth and invasiveness reveals structure-activity relationships among anti-infective indoles
Systematic benchmarking of AlphaFold and SWISS-MODEL kinase structures for structure-based drug discovery
Extraction method, structure-activity relationship and anti-tumor mechanism of Lycium barbarum polysaccharides
Large-scale comparative virtual screening identifies novel molecular targets underlying the multi-target activity of quercetin in psoriasis
High-Throughput Technologies for Targeted Covalent Drug Discovery: Recent Advances and Perspectives
Design of recyclable oligo(ethylene glycol)-ketone RAFT copolymers for in situ dioxirane-mediated epoxidation: structure-activity insights
Structure-activity relationship of calanthoside Part 2: positional effects of indole ring substitution on HFDPC proliferation
Harnessing the Power of Large Language Models for Drug Discovery: A Systematic Review of Current Applications and Future Directions
Discovery and mechanism analysis of novel TRPV1 antagonists driven by multi-dimensional virtual screening and dynamic simulation
OutSee awarded Innovate UK grant for agentic AI pilot study to enhance drug target validation
Nitrogen-Containing Heterocycles in Antibacterial Drug Discovery: Recent Advances and Structure-Activity Relationships
Oxadiazole-based Inhibitors Targeting Carbohydrate-Hydrolyzing Enzymes in Type 2 Diabetes Mellitus: Synthetic Strategies, Structure- Activity Relationships, and Translational Perspectives
Computational and Natural Product Strategies in Anti-leishmanial Drug Discovery
Skill-File-Guided Virtual Screening: A Single-Target Formyl Peptide Receptor 2 Case Study of Large-Language-Model-Coordinated Physics and Diffusion Docking
Advancing intracellular delivery with LumiPore®: A new approach to cell transfection and drug discovery
Nucleic acid aptamers: new methods for selection, target validation, molecular diagnostics and therapeutics
Schrödinger-BMS collaboration centers on Bunsen for trillion-scale computational drug discovery
INDUSTRY
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BioMarin drops Voxzogo development for Noonan syndrome as treatment landscape shifts
Standout pharma marketing takes the stage at the 2026 Fierce Pharma Marketing Awards
Connect's Dupixent rival flunks phase 2 asthma trial, but biotech sees reasons for hope
Lilly pledges up to $237M per program in CNS genetic med collab with Canadian biotech
Navigating German biotech: 10 companies to keep an eye on in 2026
Buried knowledge could cost pharma billions. Here’s how to fix it
BIOSPAIN 2026: Spain’s flagship biotech event is going annual
Axoltis misses the mark in phase 2 ALS study, but will persevere with the synthetic peptide
Corbus posts phase 1 obesity data for drug mechanism that defeated Novo, Sanofi
From Onboarding to Outcomes: The Privacy-First Identity Workflow for Pharma Marketing
Cellectis cans allogeneic CAR-Ts to hop aboard in vivo bandwagon
After FDA nod for novel Cabometyx formulation, analysts predict limited threat to Exelixis
Biopharma’s next data advantage may start with genetics
What Health Equity Champions Can Learn from Pharmaceutical Sales
Preclinical Pulse: The research catching our eye in September 2026
Top biotech deals in August 2026
How Evox Therapeutics is targeting CNS diseases with exosomes
Fierce Biotech Layoff Tracker 2026: Sionna halves staff; Merck trims more NJ jobs
Fierce Biotech Fundraising Tracker '26: RegCell wrangles $66M; Encoded finagles $275M series F
RESEARCH
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Scientists find how “zombie” cells fuel inflammation as we age
Scientists discover the human heart can regrow muscle after a heart attack
Scientists find a human-only gene that may help explain our brainpower
High blood sugar may help cancer cells hide from the immune system
Scientists find the “Achilles’ heel” of deadly gut bacteria
Scientists discover hidden “footprints of death” that may help viruses spread
The tea in your kombucha changes more than just the taste
Scientists discover why ozempic may not work for some people
Scientists discover simple way to relieve arthritis pain without pills or surgery
MIT scientists discover amino acid that helps the gut heal itself
Scientists discover vitamin B2 may help cancer cells survive
Your “um” and pauses could reveal early dementia risk
Scientists discover a weak spot shared by polio and common cold viruses
Scientists find natural compounds that hit COVID-19 from every angle
Scientists discover why Ozempic works better for some people
Scientists discover skincare compound that kills drug-resistant bacteria
Stanford scientists discover “natural Ozempic” without side effects
What’s hiding inside colon cancer could change treatment
Scientists discover sleep switch that builds muscle, burns fat, and boosts brainpower
Scientists discover why cancer drugs don’t work for everyone
TECHNOLOGY
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Parallel hierarchical gene assembly from oligonucleotide pools on an integrated digital microfluidic platform
Phytic acid-mediated polyacrylamide/chitosan/cellulose nanocrystal/PEDOT:PSS composite hydrogels with ion-electron dual conductive pathways for wearable flexible biosensors
Real-Time In Situ Imaging of Immunotherapy Efficacy: A DNA Nanowire-Based Biosensor for Granzyme A-Mediated APE1 Inactivation
An isocaudomer-assisted AND-gate Cas12a biosensor for dual-gene identification of methicillin-resistant Staphylococcus aureus
Automated sample preparation microfluidic platform for immuno-LAMP detection: application to troponin I quantification
Quantitative comparison of PI(3,5)P2 biosensors reveals SnxA is the most sensitive and unbiased
Multi-omics and spatial transcriptomics reveal that S100A10 drives CD8+ T-cell exhaustion and immune evasion in hepatocellular carcinoma through cPLA2-5-LOX-mediated arachidonic acid metabolism and ferroptosis
Spatial transcriptomics reveals atorvastatin modulates the tumor microenvironment to suppress breast cancer liver metastatic outgrowth
Quantifying HER-2 for Precision Oncology: The Role of Optical Biosensors
A Microfluidic System for Particle Enrichment by Integrating an Acoustic Field With Oscillatory Flow
Efficient fabrication of paper-based microfluidic biosensors incorporating laser-induced graphene for label-free electrochemical immunoassays
Machine learning-assisted optimization of a BK7/Ag/As₂S₃/graphene surface plasmon resonance biosensor for high-sensitivity urine glucose detection
Parafilm-laminated microfluidic cloth devices: A durable graphdiyne-based nanozyme platform for machine learning-assisted antibiotic detection
Establishing a Microfluidic Co-Culture Blood-Brain Barrier Model Using Human Brain Endothelial Cells and Astrocytes
Spatial Heterogeneity in Anaplastic Thyroid Carcinoma: Mechanistic Insights and Clinical Translation through Single-Cell and Spatial Transcriptomics
Spatial Transcriptomics Identifies Characteristic Immunological Niches in Atopic Dermatitis
Tangential single-cell spatial transcriptomics resolves early ray lineage trajectory in poplar
Engineering and materials perspective on wearable electrochemical biosensors for elite athletes: interfacial design and system integration
In-electrode faraday cage-type biosensors: Enclosing biorecognition for ultra-sensitive electrochemical and electrochemiluminescence detection
Microfluidic-Enabled Elastic Photothermal Helical Gel Microfibers for High-Efficiency Solar Evaporation With Spatially Regulated Light-Thermal-Water Management
CRISPR & GENE EDITING
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CRISPR crops are coming to Europe — why bolder would be better
A lock-and-key aptamer probe gates CRISPR/Cas12a trans-cleavage for antibiotic detection
Cellectis quits CAR-T and pivots to ‘in vivo’ gene editing
CRISPR beyond biology: building a sustainable innovation system
CRISPR beyond biology: building a sustainable innovation system
From feasibility to predictability: prime editing redefines precision breeding in plants
A steric hindrance-regulated autocatalytic CRISPR/Cas12a system for direct and amplification-free microRNA detection
CRISPR and yeast two-hybrid screens identify CD81 as a proviral host factor for PRRSV
Monitoring kinetic changes and restriction of influenza A virus RNA species during infection using a Flu-Stranded CRISPR platform
Generation of KARRIKIN INSENSITIVE2 loss-of-function mutants in Ceratopteris richardii using a CRISPR/Cas9 system based on ribozyme-gRNA-ribozyme (RGR) technology
An aptamer-regulated CRISPR/Cas12a system based on split crRNA for theophylline and tobramycin detection
Efficient genome editing in tomato using Cas12i3 variants
In vivo CRISPR screening links NFKB1 to endocrine resistance in ER+ breast cancer
CD73 disruption with tumor-specific CRISPR/Cas9 nanoparticles reduces adenosine-mediated immunosuppression and amplifies response to chemotherapy
MtvS1 and MtvS2 Interact with RNA polymerase to regulate the Francisella type V-A CRISPR-Cas system
Genetic transformation and CRISPR/Cas12a-mediated gene editing of European beech (Fagus sylvatica L.) employing a transient protoplast system
Single-cell and in vivo profiling reveal heterogeneous and organ-specific CRISPR-Cas9 off-target and translocation outcomes
Transposon end recognition and excision mechanisms of type I-F CRISPR-associated transposases
A CRISPR-based ‘dam-break drainage’ sensing architecture for rapid, affordable and ultrasensitive pathogen detection
Targeted lipid nanoparticles unlock in vivo human haematopoietic stem cell gene editing
CELL & GENE THERAPY
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Cellectis quits CAR-T and pivots to ‘in vivo’ gene editing
Cellectis cans allogeneic CAR-Ts to hop aboard in vivo bandwagon
Mesenchymal Stem Cell Therapy for Systemic Sclerosis: Current Evidence and Clinical Applications
Engineered Bacteriophages in Cancer Immunotherapy: Emerging Concepts and Potential Integration with CAR-T Cell Therapy
Author Correction: Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness
Comparison of intestinal histopathological changes following teclistamab, BCMA-directed CAR T, CD19-directed CAR T and rituximab therapies
Could Mixed CAR T-Cell Products and Overlapping Patients Overestimate the Risk of HLH With Tisagenlecleucel?
Engineering next-generation CAR-T cells for glioblastoma treatment: a review of innovations in receptor design, antigen targeting, and therapeutic persistence
Relapse and progression after CAR-T cell therapy in large B-cell lymphoma: Patterns, mechanisms, and salvage strategies
Immune Toxicities After CAR-T and Bispecific T-Cell Engager Therapies
Glycocalyx-edited mesenchymal stem/stromal cell therapy in advanced osteoporosis
Bioengineered cell therapies for pediatric solid tumors: unmet needs and a measurement-integrated approach
Cancer-driver-agnostic targeting of amplified surface proteins identifies MPZL1 for selective CAR-T cell therapy
Donor-Derived CD19-CAR-T Therapy in Combination With TKI Cures Uncommon Ph-Like Mixed-Phenotype Acute Leukemia With Lineage Switch to Ph+ Acute Lymphoblastic Leukemia: A Case Report
Recurrent oral ulceration after CD19 CAR T-cell therapy defines a delayed mucosal inflammatory phenotype
CART-8 and cardiovascular risk stratification: informing, not restricting, CAR-T therapy
Updating risk stratification for CAR-T cell-related cardiovascular toxicity: from CART-7 to CART-8
UCLA researchers develop scalable TCR therapy for solid tumors
Advancing intracellular delivery with LumiPore®: A new approach to cell transfection and drug discovery
A cancer therapy put severe rheumatoid arthritis into remission
BIOPRINTING
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Exploring a cold-gelled whey protein-based ink for applications in cultured meat 3D bioprinting
3D Bioprinting Approaches for Dental Pulp Regeneration: A Scoping Review
3D bioprinting of stromal vascular fraction enriched with MXenes for enhanced intestinal regeneration
Cell-laden 3D bioprinted hydrogels for wound healing: cellular mechanism, bioprinting determinants and translational perspectives
Inkjet biofabrication of electroactive rGO/growth-factor micropatterns on electrospun PLCL for guided neural cell responses
Leveraging Navier-Stokes Principles to Engineer Perfusable Bioorgans: A Physics-Guided Paradigm for Bioprinting
Characterization and in vitro evaluation of double cross-linked PVA/chitosan-alginate biocomposite scaffolds coated with turmeric extract produced by 3D bioprinting
Development of a 3D-bioprinted tumour-on-chip with tunable hydrogel properties for monitoring colorectal cancer cell migration and invasion
Magnetically Driven Biofabrication for Tissue Engineering: From Nanoparticle Design to Mag-ATMP Translation
Advancing European standards and regulations for 3D bioprinting
Three-Dimensional Bioprinting in Reconstructive Plastic Surgery: A Comprehensive Review
Next-generation hydrogels and strategies to recreate 3D tumour microenvironments for osteosarcoma: from bioprinting to therapeutic testing
3D Bioprinted Alginate-Gelatin-Collagen Based Hydrogels Laden With Fibroblast and Keratinocyte Cells Show Potential for Regeneration of Injured Skin
Photocurable Allyl-Succinylated Collagen Bioink for High-Resolution 3D Bioprinting and Regenerative Diabetic Wound Healing
Robotic In Situ Bioprinting in Tissue Engineering: Technologies, Challenges, and Clinical Perspectives
Bioprinted core-shell living material platform for spatially controlled encapsulation of Bacillus subtilis and sustained metabolite exchange
Bioprinting of Biomimetic Periosteum-Bone Integrated Scaffolds
A one-step volumetric biofabrication platform for complex hydrogel-based hollow biomaterials
Initial safe(r)-by-design assessment of printable konjac-agar-pectin hydrogels for future extrusion-based bioprinting applications
Multifunctional Three-Dimensional Bioprinted Scaffolds Reduce Epidural Fibrosis and Promote Bone Regeneration in a Laminectomy Model
PRECISION MEDICINE
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Electra targets $342m IPO to fund hyperinflammatory syndrome drug’s pivotal trials
Evvy raises $40M to expand precision medicine for vaginal health
Looking to the Future: How Will Personalised Medicine Impact Facial Plastic Surgery
Bridging the Gap: Precision Oncology for Cancers of Unknown Primary
Pharmacogenomics and artificial intelligence in cardiovascular disease: emerging tools for precision medicine
Clinical AI and Precision Medicine: Philosophical Questions About Labels, Disease, and Evidence
Personalized medicine requires personalized delivery: Home-based phototherapy for vitiligo
Quantifying HER-2 for Precision Oncology: The Role of Optical Biosensors
Overcoming cancer resistance in pancreatic cancer: toward dynamic precision oncology
A global digital navigator of human health for precision medicine
Antibody-drug conjugates in treatment-resistant hepatocellular carcinoma: mechanistic insights, translational barriers, and a blueprint for salvage-line precision oncology
Visualizing and Targeting Tumor-Associated Neutrophils: Advanced Imaging, Therapeutic Reprogramming, and Cell-Based Delivery for Precision Oncology
Role of OPRM1 A118G polymorphism in tramadol analgesia following third molar surgery: a pharmacogenomic study
Real-world pharmacogenomics-guided antihypertensive treatment response in clinical practice underrepresented population: implications for precision prescribing and medication safety
Interpreting insomnia symptoms in evening types requires a precision medicine approach
Ensemble learning of pathology foundation models for precision oncology
Barriers and facilitators to the implementation of pharmacogenomic testing for antidepressants use in primary care: a systematic review using the consolidated framework for implementation research
A cellular Digital Twin framework for predictive and mechanistic modeling of drug responses in precision medicine
Cell targeting peptide guided nanomedicine: a new paradigm in precision oncology for the management of non-small cell lung cancer
Obesity-driven adipokine signaling in breast cancer: mechanistic insights, therapeutic challenges, and opportunities for precision oncology
STEM CELLS
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Low-dose taxanes induce γδ-T cell reprogramming and ANXA6/PPP2R1A release to synergistically treat triple-negative breast cancer
Mesenchymal Stem Cell Therapy for Systemic Sclerosis: Current Evidence and Clinical Applications
Using Patient iPSC-derived Retinal Pigment Epithelium to Evaluate Differential Susceptibility to MEK Inhibitor-Associated Retinopathy
Generation of eight-cell embryo-like cells from human pluripotent stem cells
Evaluating and comparing the signalling and functional landscape of hiPSC-CMs derived from patients with dilated cardiomyopathy
Evaluating and comparing the signalling and functional landscape of hiPSC-CMs derived from patients with dilated cardiomyopathy
Bupleuri Radix- Aurantii Fructus Immaturus pair attenuates metabolic dysfunction-associated fatty liver disease in association with modulation of PI3K/Akt-GSK3β/FoxO1 pathway: Evidence from multi-model validation including human iPSC-derived liver organoids
Differentiation of human embryonic stem cells into adrenal chromaffin-like cells with catecholamine markers, excitability, and Ca2+ signaling
3D-Printed Collagen/Silk Fibroin/Matrigel Scaffold Combined with iPSC-Derived Cells for Tissue Regeneration of Salivary Glands
Functional precision psychiatry: iPSC-derived neurons as predictive assays for antidepressant response
Functional precision psychiatry: iPSC-derived neurons as predictive assays for antidepressant response
Co-Delivery of Sustained Release Chondroitinase ABC-37 With Human iPSC-Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke
CRISPR and Gene Augmentation Rescue Trabecular Meshwork Dysfunction in iPSC Models of Lowe Syndrome
Pharmacological modulation of GLI signaling promotes human iPSC-derived cardiomyocyte maturation via PGC1α-associated mitochondrial programs
Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows age-related methylation is reset during stem cell reprogramming
Evaluating the pathogenic significance of unique chromosomal variants in craniosynostosis using patient-derived induced pluripotent stem cells and mouse modelling
Progress in Intra-Arterial Stem Cell Therapy for Ischemic Stroke: A Review
Human iPSC-derived vascularized organoids: strategy-based insights from 2D endothelial cells to 3D blood vessel organoids
Author Correction: Cryopreservable dopaminergic progenitors derived from human iPSCs with accelerated loss of pluripotency and early functional restoration in Parkinsonian rats
A common vape flavoring may disrupt early embryo development
NEW APPROACH METHODS
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Finding a place for new approach methodologies (NAMs) in biomedical research
Applications of in vitro new approach methodologies (NAMs) in drug development: A scoping analysis of titles of nonclinical study reports submitted to the FDA
Evaluating local neurotoxicity potential of extractables and leachables: Comparison of in vivo and in vitro data and need for new approach methods
Expanded evaluation of a robust on-line sample cleanup-LC-MS platform suited for new approach methodologies (NAM)
Advances in New Approach Methodologies at FDA's Division of Applied Regulatory Science
The Current Status of the 3Rs Principles in Animal Use in Bosnia and Herzegovina: Overview and Future Perspectives
Histotechnology at the crossroads of innovation: why morphology is the foundation of New Approach Methodologies
Integrating new approach methodologies and artificial intelligence to advance central nervous system toxicity prediction: lessons from preclinical and clinical case studies
Laboratory animal science cannot afford sex bias: Aligning the 3Rs with sex-inclusive research
Toxicologic Pathology Forum: ESTP/STP Working Group Opinion on the Evolving Landscape of New Approach Methodologies in Drug and Chemical Safety Development
State of the industry: integration of 3Rs principles and new approach methodologies in non-clinical product development through fit-for-purpose
Current and emerging new approach & methodologies for skin hazard assessment
From "wish-list" to successful delivery: Opportunities for multidisciplinary and multisectoral engagement in implementation of strategies to phase out animal testing
Beyond monolayers: a comparative analysis of 2D cell cultures and 3D in vitro models as new approach methodologies
A proposed evaluation of new approach methodologies for dermal toxicity assessment of botanicals
Toward Animal-Free Phototoxicity Testing: A Keratinocyte-Based UVA Screening Assay to Distinguish Photoirritation from Photoallergy
Role of non-animal 3D models in H. pylori associated gastric carcinogenesis: Insights and future perspectives
Supporting 3Rs approaches in biologicals testing: responses from a survey of Manufacturers, Contract Research Organisations, National Control Laboratories and National Regulatory Authorities
Can microbial biomass deliver the techno-functional properties required for more sustainable, animal-free foods? A quantitative synthesis linking microbial biomass type, processing, and techno-functionality
A chemically optimized, GalNAc-conjugated siRNA targeting HSD17B13 demonstrates efficacy in a human 3D organoid model of MASH, showcasing an alternative to animal testing
FUNDING & VC
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IMMUNOTHERAPY
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Immune checkpoint inhibitors in advanced upper-tract urothelial carcinoma: a multicenter study
Real-world treatment patterns and outcomes in metastatic clear cell renal cell carcinoma following immune checkpoint inhibitor progression (2018-2023)
Targeting BLVRB Overcomes Immunosuppression and Potentiates Immunotherapy in Monocytic Acute Myeloid Leukemia
Mesoporous polydopamine-based nanodrug delivery systems for tumor immunotherapy
Immune checkpoint inhibitor-related colitis: Mechanisms, diagnosis, and treatment
pH-Responsive liposomes co-delivering a membrane-active peptide and the PI3Kγ inhibitor to reconstruct the tumor microenvironment for enhanced antitumor immunotherapy
Scholar Rock scores long-awaited FDA approval, the first for muscle loss in SMA
Roche, MediLink notch phase 3 lung cancer win but trail GSK on cross-trial survival
Composite clinical scores in real-world extensive-stage small-cell lung cancer patients treated with chemo-immunotherapy
Editorial Comment: Preoperative Nutritional Risk Defines Treatment Tolerance and Guides Adjuvant Immunotherapy in Resectable Esophageal Squamous Cell Carcinoma
Unlocking the clock: a systematic review and meta-analysis on optimizing immune checkpoint inhibitor timing for advanced solid tumors
Targeting CD38 with bispecific antibody XmAb 18968 in patients with relapsed/refractory acute myeloid leukemia and T-cell acute lymphoblastic leukemia
From fixed antibody-drug conjugates to programmable therapeutics
Response of Perineurial Tumor Spread from Cutaneous Squamous Cell Carcinoma Treated with Immunotherapy
First-line fecal microbiota transplantation for the management of immune checkpoint inhibitor-mediated diarrhea and colitis
An immune related cell death index for prognostic stratification and immunotherapy response prediction in oral cancer
Real-Time In Situ Imaging of Immunotherapy Efficacy: A DNA Nanowire-Based Biosensor for Granzyme A-Mediated APE1 Inactivation
Author Correction - with Update (U+C): Miniature and versatile genome regulation TnpB-ωRNA toolkits facilitate cancer immunotherapy
Scientists turn probiotic bacteria into tiny drug factories for pancreatic cancer
Gilead and Nucleai probe why target-positive tumors can still resist ADCs
MICROBIOME
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Microbiome and atherosclerosis: hype or future therapeutic target?
Dietary index for gut microbiota (DIGM) and cardiometabolic, inflammatory, and gut–brain-related biomarkers in adults with obesity: a cross-sectional study
Symbiotic interactions and climate change implications of the octocoral microbiome
Host-microbiome interactions and enteric pathogen infections - from early-life to long-term impacts on gut-brain communication
The canine gut microbiome as a translational model for human health and aging
Gut microbiota modulates Hyodeoxycholic Acid to Inhibit Leukemia Development
Donor Microbiota Features Associated With Liver Transplant Recipient Infectious Complications: A Pilot Study Using Deep Intestinal Sampling During Liver Procurement
Intestinal Serotonergic Vagal Signaling as a Mediator of Microbiota-Induced Hypertension
The Oral Microbiome-Inflammaging Axis in Elderly Periodontitis: Emerging Immunopathogenic and Systemic Mechanisms
Individual identification and time since deposition estimation based on community structure and absolute abundance of the exposed vaginal microbiome
Assessing the potential of biologically-activated carbon treatment, pasteurization, and particle filtration as pre/pro-biotic controls on premise plumbing microbiomes
Drug–microbiome–host interactions: antimicrobial effects of non-antibiotic compounds
Dietary fiber source-dependent modulation of pregnant sow fecal microbiota, gas profiles, and short-chain fatty acids in vitro
Drug-microbiome-host interactions: antimicrobial effects of non-antibiotic compounds
Gut Microbiota Dysregulation in Dementia: Molecular Mechanism Linking the Gut-Brain Axis to Neurodegeneration
Dietary iron imbalance disrupts enterohepatic homeostasis via the gut microbiota-bile acid-FXR signaling axis
Glutathione peroxidase in inflammatory bowel disease: From ferroptosis, immunity, and microbiota regulation to targeted nanomedicines
Antifungal therapy improves microbiome dynamics in inflammatory bowel disease
Common medications may change your gut for years
Gut microbiota-derived acetate mitigates Escherichia fergusonii-induced gut dysbiosis exacerbating Klebsiella pneumoniae pulmonary infection in mice
CARDIOVASCULAR
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Platelet–NK cell interplay in advanced coronary artery disease is associated with pre-exhausted NK cell dysfunction without upregulation of the immune checkpoint receptor NKG2A
Microbiome and atherosclerosis: hype or future therapeutic target?
Concomitant PLACK Syndrome, MYBPC3-Related Cardiomyopathy, and Nutritional Deficiency
Letter to the Editor: Re: "Prediction of clinical outcomes based on phenotypic grouping using left ventricular and left atrial strains in patients with heart failure with preserved ejection fraction"
Natural Missplicing Events Amplified by an Elusive Deep-Intronic MYBPC3 Variant Cause Hypertrophic Cardiomyopathy
Dysregulated Ribonucleoprotein Granules Impair Mitochondrial Function in RBM20-Related Dilated Cardiomyopathy
Linking Coronary Microvascular Dysfunction to Cardiac Troponin Elevation in Transthyretin Amyloid Cardiomyopathy
Exercise Training for Patients with Heart Failure with Preserved Ejection Fraction: A Systematic Review and Bayesian Network Meta-Analysis
Letter: Novel Mechanistic Perspectives on SGLT2 Inhibitor Benefits After Acute Myocardial Infarction: NLRP3 Inflammasome Modulation and Autophagy-Mitochondrial Quality Control
Switching to Angiotensin Receptor-Neprilysin Inhibitor and Reduced Risk of New-Onset Atrial Fibrillation in Heart Failure with Reduced Ejection Fraction: A Nationwide Propensity Score-Matched Study
Prospective Systematic Screening for Transthyretin Amyloid Cardiomyopathy in Cardiology Inpatients With Left Ventricular Hypertrophy: the IMPACT Study
Identification and reporting of heart failure with preserved ejection fraction in Sub-Saharan Africa: a scoping review of diagnostic approaches, echocardiographic assessment, and evidence gaps
Hypertensive heart disease and HFpEF:atrial functional valve regurgitation as the trigger of acute heart failure in a syndrome of exertional dyspnoea
Periodontitis and adverse outcomes in atrial fibrillation: prospective evidence from the UK Biobank
DREADDs-Gi mediated inhibition of myeloid cells leads to anti-inflammatory signalling, shrinkage of microglia and acute heart failure in Cx3cr1Cre mice
Letter by Qi and Wang Regarding Article, "Prognostic Implications of Evolving Universal Definitions of Periprocedural Myocardial Infarction in Patients With Acute Coronary Syndrome"
Letter by Xu et al Regarding Article, "Dapagliflozin to Reduce Early Recurrence After Catheter Ablation for Atrial Fibrillation: The DARE-AF Randomized Clinical Trial"
Response by Zhao et al to Letter Regarding Article, "Dapagliflozin to Reduce Early Recurrence After Catheter Ablation for Atrial Fibrillation: The DARE-AF Randomized Clinical Trial"
Giant Left Ventricular Pseudoaneurysm Complicating Myocardial Infarction
Triglyceride–glucose index‑integrated nomogram for six‑month outcomes after acute ST-elevation myocardial infarction
ONCOLOGY
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Less Overdiagnosis In Breast Cancer Screening Than Thought, Study Finds
Taiho, Cullinan report improved PFS in Phase III NSCLC trial
Progesterone reshapes the tumor immune microenvironment toward macrophage-driven immune suppression in hormone receptor–positive breast cancer
Most Appendix Cancer Patients Can Skip Chemo, Study Says
Folate-targeted Mg–alendronate BioMOF nanorods for pH-responsive drug release and selective cancer therapy
GSK prepares frontline FDA bid for Jideytro, its first lung cancer drug
Cancer Is Now The Leading Health Threat For 9/11 Survivors 25 Years On
Cancer treatment alters mutant selection in normal esophagus
The signal that changes everything: understanding MRD in oncology drug development
UCLA researchers develop scalable TCR therapy for solid tumors
AI model predicts which breast-cancer drugs work best
After decades of trial failures in chemotherapy-linked neuropathy, psilocybin shows promise in preventing it in mice
FDA Approves New Pill, Etcamah, For Advanced Breast Cancer Guided By Blood Test
Scientists find a new weakness in treatment-resistant prostate cancer
CD73 disruption with tumor-specific CRISPR/Cas9 nanoparticles reduces adenosine-mediated immunosuppression and amplifies response to chemotherapy
GSK Pays $110M for Phase 1-Ready Hutchmed Asset in a New Class of Cancer Drugs
Scientists find breast cancer cells hiding behind protective “shields”
Bladder cancer treatment: where are we standing in 2026?
A cancer therapy put severe rheumatoid arthritis into remission
A binding-to-release strategy for targeted anticancer drug delivery
NEUROSCIENCE
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Microprotein Atlas Links Brain Immune Cell Dysfunction to Alzheimer’s
Depression in Parkinson's Disease: Real-World Prescribing Patterns and Treatment Dynamics from a Nationwide Greek Cohort
A parsimonious three-gene mitochondrial classifier from frontal cortex for Alzheimer's disease: Nested cross-validation and multicenter external validation
Altered neurovascular coupling in mild cognitive impairment and Alzheimer's disease: Associations with polysomnography-derived sleep parameters and cognition
Associations of plasma lipid burden with cognitive performance and decline across dementia with Lewy bodies, Alzheimer's disease, and Parkinson's disease dementia
Rethinking the concept of disease modification in an evolving Parkinson's disease treatment landscape
Nanomaterial Interventions in Pathological Biomolecular Phase Transitions of Neurodegeneration and Cancer
Resilience mechanisms in Parkinson's disease: a domain-specific conceptual framework
Social Media Claims About Blood Tests for Alzheimer's Disease and Dementia: A Cross-Sectional Content Analysis
Structural abnormalities in gray matter, white matter, and cerebrospinal fluid in parkinson's disease: a voxel-based morphometry study
Brain fluorodeoxyglucose PET anatomical segmentation via AI: extensive validation in the neurodegenerative spectrum
The diagnostic biomarker problem in amyotrophic lateral sclerosis
Non-coding RNAs and Mitochondrial Dysfunction in Alzheimer's Disease: A Systematic Review
Characterising the motif composition and allele length distribution of ZFHX3 GGC repeat expansions in amyotrophic lateral sclerosis
Cerebral perfusion correlates of domain-specific cognitive function in Alzheimer's disease and dementia with Lewy bodies
Somatic mosaicism in the brain: linking development, ageing and neurodegeneration
A microprotein atlas of the human frontal cortex in Alzheimer's disease
Triptolide preserves cognitive function and reduces hippocampal inflammation in a mouse model of Alzheimer's disease
Scientists find a new layer of Alzheimer’s hidden in the genome
Retinoic acid-treated human umbilical cord-derived mesenchymal stem cells attenuate Alzheimer’s disease in an animal model
INFECTIOUS DISEASE
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ABC and MFS efflux transporters mediate antibiotic resistance and bile salt tolerance in Enterococcus faecalis
Association between early prehospital administration antibiotic and 28-day mortality in sepsis
ESAT-6-derived lipopeptide-based mucosal vaccine elicits distinct humoral immune responses concomitant with a reduction in mycobacterium infection
Effects of nanominerals on the photochemical transformation of antibiotics in surface waters
SARS-CoV-2 management strategies in B-Cell-depleted people with multiple sclerosis: from prevention to antiviral treatment
Use of standard definitions for the extent of antibiotic resistance in bacteria: a systematic review and framework for future consensus definitions
Antibiotic resistance mutations in Mycoplasma genitalium and non-gonococcal urethritis treatment outcomes
Efficacy of antibiotic-loaded calcium sulphate pellets in the surgical management of chronic hematogenous osteomyelitis in children: a retrospective comparative study
Real-Time Single-Aggregate Analysis of Vaccine Antigen Stability via Stochastic Electrochemical Blocking
Examining the current image-guided biopsy and empiric antibiotic paradigm for suspected spondylodiscitis
A lock-and-key aptamer probe gates CRISPR/Cas12a trans-cleavage for antibiotic detection
GSK makes ‘difficult decision’ to shutter German flu vaccine manufacturing site
Knowledge, Attitudes, and Self-Reported Tetanus-Toxoid-Containing Vaccine Uptake Among Women Aged 15-44 Years in Ifakara Town, Tanzania: A Community-Based Cross-Sectional Study
Therapeutic cancer vaccines: development, challenges, and future perspectives
Drug-microbiome-host interactions: antimicrobial effects of non-antibiotic compounds
Remdesivir Maintains Antiviral Potency Against Clinically Relevant SARS-CoV-2 Nsp12 Substitutions
An IMS 1313-Based Inactivated PRV Vaccine with a novel immunopotentiator induces Robust Protective Immunity against Virulent Variants
Study shows mRNA vaccines trigger more diverse flu antibody responses
Highly efficient intranasal H5N1 vaccine based on a safe vesicular stomatitis virus (VSV) vector
Enhanced antitumor immunity of mRNA vaccines by bioorthogonal-like delayed activation of exogeneous STING
LIQUID BIOPSY
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Circulating tumor DNA-guided de-escalation or escalation of adjuvant therapy in high-risk stage II and stage III colon cancer: the phase 2 PEGASUS trial
Beyond copy number: circulating cell-free mitochondrial DNA Fragmentomics and structural states in liquid biopsy
Analyzing model inaccuracy and relative importance of parameters of discrete model of adhesion of circulating tumor cells for investigating metastatic dynamics
ASO Author Reflections: Liquid Biopsy in Resected Pancreatic Ductal Adenocarcinoma-From Prognostic Association to Clinical Utility
The effect of unique molecular identifier family size using tumor-informed circulating tumor-DNA analysis in childhood cancers
Towards a Robust cell-free DNA Isolation Protocol for NGS Applications in a Clinical Molecular Diagnostics Setting
Recurrence and Circulating Tumor DNA in Human Papillomavirus-Positive Oropharyngeal Cancer: A Meta-Analysis
Beyond traditional biopsy: integrating liquid biopsy, molecular panels, and advanced imaging techniques in thyroid cancer management
Targeted NGS of Preoperative Circulating Cell-Free DNA in Colorectal Cancer
Predictive Value of Perfusate Cell-free DNA During Hypothermic and Normothermic Machine Perfusion of Donor Kidneys
Prospective Evaluation of Circulating Tumor DNA in Metastatic Hormone-Sensitive Prostate Cancer
Personalized Circulating Tumor DNA Analysis for Predicting Outcomes and Tracking Response to Radiotherapy and Pembrolizumab in Localized Sarcomas: Analysis of the SU2C-SARC032 Trial
Systemic metastases in a BRAF V600E-mutant pleomorphic xanthoastrocytoma classified by DNA methylation: treatment with BRAF/MEK inhibitors and liquid biopsy monitoring
Beyond CA-125: circulating cell-free DNA as the next-generation biomarker in ovarian malignancy
ASO Visual Abstract: Urine Cell-Free DNA in the Diagnosis of Intraductal Papillary Mucinous Neoplasms: A Prospective Observational Study
Liquid biopsy: a new window on the BRCA genes
Cost-Effectiveness of liquid biopsy screening for gastric cancer in the United States
Circulating cell-free DNA and NETosis-related biomarkers in schizophrenia: association with clinical features and treatment
Circulating tumor cells identify a disseminated genomic high-risk phenotype within IMS-IMWG 2025 staging in newly diagnosed multiple myeloma
Decoding ctDNA: biological insights for accurate clinical interpretation