Live News Categories
ORGAN-ON-CHIP
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CN Bio announces expert speaker line-up and scientific program for inaugural Organ-on-a-chip e-Symposium
Engineering human multi-organ tissue chip niches for drug absorption, distribution, metabolism, excretion and toxicity prediction
Real-time integrated and multiplexed electrochemical sensor for reactive oxygen species in a high-throughput microphysiological system
Microphysiological Systems Integrating Bioprinting, Organoids, Organ-on-a-Chip, and AI: Next Generation Platforms for Pharmaceutical Development
Artificial intelligence across Organ-on-a-Chip workflows: current implementations and future approaches
Bridging the gap: using organ-on-a-chip technology to evaluate nanoparticle enzyme replacement therapy for lysosomal storage diseases
Hydrogels and microfluidics: toward more physiologically relevant organ-on-a-chip models
A human iPSC-derived kidney-liver organ-on-a-chip platform for modeling inter-organ crosstalk
Modeling sympathetic neuro-cardiac interactions in a hiPSC-based microphysiological system
Advantages, considerations and challenges in using Electrochemical Impedance Spectroscopy to monitor tissue integrity and cell differentiation in Microphysiological Systems
Functional assessment of cardiac beat dynamics under dynamic flow: insights from the Mera microphysiological system
Chemical Distribution Kinetics of Five Polycyclic Aromatic Hydrocarbons in a Microphysiological System
Recent Advances in Alternate Corneal Models for Ophthalmic Safety Testing and Efficacy Studies: A Special Focus on Organ-on-a-Chip, Organoid, and 3D Models
Muscle Organoids and Organs-on-Chips: A 15-Year Global Bibliometric Perspective
Editorial: Innovative approaches for disease modeling using organoids and organ-on-a-chip
Organ-on-a-chip platforms for disease modeling and in vitro diagnostic applications
Three-dimensional cell culture models in oncology: From tumour spheroids to integrated microphysiological systems
Stimuli-responsive materials in organ-on-a-chip systems: from dynamic microenvironment modelling to functional readout
hiPSC-derived Organoids and Organ-on-chip Systems: New Frontiers in Neural Tube Defect Research
Integration of multi-stacked biodegradable PLGA membranes into microfluidic organ-on-a-chip devices for tunable barrier co-culture
ORGANOIDS
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Recording time via brain organoids
Brain organoids grafted into cortex-free mice will advance human brain research
Acetaminophen produces limited molecular and functional effects in human cortical organoids
Iterative Optimization of Photoactivatable BRD4 Degraders for Aging-Amplified Immunotherapy in Patient-Derived Lung Cancer Organoids
CDK2/9 blockade remodels chromatin and drives phenotypic plasticity in glioblastoma organoids
Lipopolysaccharide-induced alterations in barrier integrity and inflammatory signaling in porcine small intestinal organoids
Protocol for analyzing autophagy-related cellular phenotypes in autophagy-deficient human embryonic stem cell-derived lacrimal gland-like organoids
Establishment of Uveal Melanoma Patient-Derived Organoids Using an Air-Liquid Interface System for Translational Research
Pediatric Human Olfactory Epithelium Mirrors Adult Structure and Function in a Human Olfactory Organoid Model
Vascularized human skin assembloids model compartmental skin organization and immune responsiveness in vitro
Improved Method for Obtaining Patient-Derived Glioblastoma Organoid and Primary Cells: A Generic and Simplified Approach for Intracranial Tumor With Minimized Input
Molecular and Proteomic Profiling of Human Cerebral Organoid‑Derived Small Extracellular Vesicles
GLP-1R agonist semaglutide protects human forebrain organoids from cholesterol-induced neurotoxicity
Polymyxin B Attenuates Sepsis-Induced Acute Kidney Injury by Activating a SUMO1-p65 "Molecular Brake" in Kidney Organoids
Powering the liver toxicity assessment in the organoid era
In the era of AI, omics and organoids, animal models are still needed in cardiovascular research
Organoids: Current Applications and Future Directions
Cell-autonomous restoration of splicing homeostasis and RP11 phenotype in patient-derived RPE and retinal organoids by PRPF31.AAV gene therapy
Human brain assembloids as a model of anaesthetic-induced neural dynamics in vitro
Electrical stimulation elicits space- and parameter-dependent spiking responses in human cortical organoids
DIGITAL TWINS
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Voice-Enabled Virtual Patients for Interactive Training in Standardized Clinical Assessment: Mixed Methods Pilot Study
A digital twin for tracking and forecasting glycemia with septic patients in ICUs
Clinical trials in a dish: cardiometabolic drug development with biological and digital twins
Digital Twins and Offline Reinforcement Learning for Mechanical Circulatory Support Decisions: What the Current Evidence Can and Cannot Support
Quantitative Compression Ultrasound via a Force-Area Digital Twin for Mechanistic Assessment of Venous Thrombosis
In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence
A data-driven digital twin of emergency department flow to quantify congestion dynamics and test operational resilience
Digital twins and the virtual epileptic patient: Toward simulation-based neurology
A Diffusion-Based Digital Twin for Predicting Road Deterioration under Climate and Traffic Stress
Knowledge Acquisition, Case Discussion, and Engagement in Health Professional Students Using Interactive Virtual Patient Cases Versus Written Case Studies: Randomized Controlled Trial
In-process large language model requesting through knowledge graphs for interfacing with manufacturing digital twins
Harnessing digital twins for public health surveillance and pandemic preparedness
Review of Multi-Scale Bridge Monitoring: An Information-Centric Framework Integrating Ground-Penetrating Radar, Distributed Optical-Fibre Sensing, and Satellite Remote Sensing for Bridge Digital Twins
Expanding research on clinical agent data to a virtual space of location, time, and context: exploration of data structures and limitations using a pragmatic digital twin
Accuracy of virtual patient reconstruction for complete arch implant-supported prostheses with extraoral scan body-assisted registration
Development of a Lower Limb Digital Twin Model for Analyzing Femoral Injuries in Elderly CPC Subjects
Digital Twins for Targeted Therapy in Head and Neck Cancer: From Molecular Stratification to Resistance-Aware Combination Strategies
Dynamic simulation and digital twins in atrial fibrillation: Complementary roles and current limitations
Artificial Intelligence-Driven Norepinephrine Control Using Adaptive Cardiac Digital Twin for Critical Care Patients
Artificial intelligence-driven digital twins in Pharma 4.0: transforming smart manufacturing, predictive quality assurance, and personalized drug delivery
AI & MACHINE LEARNING
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Development and Validation of an Interpretable Machine Learning Model for Osteoporosis Prediction Using Multimodal Musculoskeletal Ultrasound and Clinical Features
Recommendations for the Development and Implementation of Generative Artificial Intelligence Tools in Pediatric Clinical Care: Policy Statement
‘We’ve been taking our time’: Buzzy AI biotech Xaira reveals antibody platform, first taste of pipeline
How Flagship's Valo is reshaping AI drug discovery with human data
Machine learning-based source-level EEG functional network biomarkers of antidepressant treatment response in major depressive disorder
Genome-wide transcriptomics and a machine learning-based random forest model identify novel biomarkers to predict phenotypic variability in Wilson disease
Artificial Intelligence and machine learning in toxicogenomics for drug safety assessment: a critical review
A Facial Foundation Model for Clinical Biomarker Prediction and Real-World Mobile Deployment
Portable Deep Learning-Assisted Device for Automated Interincisal Opening Assessment and Oral Submucous Fibrosis Lesion Identification: A Translational Clinical Study
Glabridin and Glabrene from Glycyrrhiza glabra L. as Natural Co-operative Modulators of the Human Serotonin Transporter: Evidence from Docking, Molecular Simulations and Machine-Learning QSAR Models
Artificial intelligence-guided green and circular nanotechnology: designing sustainable, biodegradable, and bioresponsive nanocarriers for next-generation precision drug delivery
Artificial Intelligence in MASLD: A Three-Level Framework Across Clinical, Health-System, and Policy Decisions
Artificial intelligence and vascular surgeons in patient communication: A comparative analysis of intelligibility and clinical appropriateness in acute deep vein thrombosis
Graph theory-based machine learning for automated fibromyalgia diagnosis using fMRI during an emotional task
From voxels to models: a multi-center voxel-based morphometry study identifying robust biomarkers for deep learning classification of schizophrenia
Integrative transcriptomic and machine learning analysis identifies candidate biomarkers and immune features in diabetic ulcers
Toward precision hernia surgery: integrating biomarkers, genomics, quantitative imaging, and artificial intelligence in abdominal wall repair
Artificial intelligence for mucus plug assessment: toward a new generation of airway imaging biomarkers
[Artificial intelligence-driven early warning for severe pneumonia: pathways and challenges from data integration to clinical decision-making]
‘A plate of spaghetti’: Talus Bio boasts 5,000-fold faster drug screening by skipping protein folding
CLINICAL TRIALS
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BMS gains two pivotal trial wins in lung disease and rare cancer
The effects of intraoperative low-dose dexmedetomidine on postoperative systemic inflammation and cognitive outcomes in elderly patients: Secondary analysis of a randomised controlled trial: Erratum
Envonalkib Versus Crizotinib in Treatment-Naive ALK-Positive Non-Small Cell Lung Cancer: Final Efficacy and Biomarker Analyses of the Randomized Phase III Study
At-home subcutaneous atezolizumab for non-small cell lung cancer: a prospective, single-arm phase II feasibility study
A Phase 3, Multicenter, Randomized, Placebo-Controlled Trial Evaluating the Efficacy, Safety, and Tolerability of Serdexmethylphenidate/d-Methylphenidate Capsules in Chinese Children with Attention-Deficit/Hyperactivity Disorder
Land- and water-based supervised exercise intervention for women with fibromyalgia: a CERT-based protocol from the al-Ándalus randomized controlled trial
N-acetylcysteine mouthwash for prevention of oral mucositis in hematopoietic cell transplant recipients: a double-blind randomized controlled trial
Repeated remimazolam sedation for interstitial brachytherapy in cervical cancer: a randomized controlled trial
REVERCE II: A Phase II trial of regorafenib followed by anti-EGFR therapy versus reverse sequencing in refractory metastatic colorectal cancer
PSMA-PET/CT-guided Intensification of Radiation Therapy for Prostate Cancer (PSMAgRT): 5-yr Analysis of a Phase 2 Randomized Controlled Trial
CEUS- versus US- and CT-guided Biopsy for Subpleural Lung Lesions: A Prospective, Multicenter Randomized Controlled Trial
TISA-818, an Anti-inflammatory Conjugate of Montelukast-Decapeptide, in Acute Respiratory Distress Syndrome Due to Pulmonary Infection: A Phase 2 Randomized Trial Using the 2023 Global Definition
Comparative Efficacy of Leukocyte-Rich and Leukocyte-Poor PRP for Lateral Epicondylitis on Isokinetic and Isometric Upper Limb Strength under an Identical Rehabilitation Protocol: A Randomized Controlled Trial
Cost effectiveness of outpatient balloon catheter induction of labor compared with inpatient prostaglandin: Economic analysis alongside the OBLIGE randomised controlled trial
Contingency management plus deep transcranial magnetic stimulation for the treatment of cocaine use disorder: Protocol of a randomized controlled trial
Effects of exercise and educational programs on long-term quality of life, anxiety, and depression in breast cancer survivors: an exploratory secondary analysis of the Setouchi breast project-10 randomized controlled trial
Comparison of Methylprednisolone and Dexamethasone in Their Interaction With Sugammadex in Pediatric Patients: A Randomized Controlled Trial
Carbon nanoparticle-Fe (II) complex for ferroptosis therapy in refractory solid tumors: a phase I trial
Systemic and Mucosal Antibody Responses Against Neisseria gonorrhoeae (Ng) Outer Membrane Vesicle Antigens following Four-Component Meningococcal Serogroup B (4CMenB) Immunization in Healthy Adults: A Randomized Phase II Trial
Response to the letter to the editor- phase III trials in retinal biosimilars: parity before pragmatism
REGULATORY
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Asahi Kasei Acquisition Pays Off With FDA Approval for Novel Herpes Drug
Abbott nabs FDA approval for new CardioMEMS HF System that allows heart readings to be seen at home
Teva secures FDA approval for Degevma biosimilar
A Heart Valve That Grows Up With The Patient Wins FDA Approval
Structure-based drug repurposing for CDK6: Molecular docking and molecular dynamics characterization of FDA-approved non-oncological compounds
New FDA-Approved Treg Therapy to Reduce Chronic GVHD After Allogeneic HSCT
Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report
US Food and Drug Administration Officials' Public Statements on Regulatory Flexibility in New Drug Approval, 2021-2024
Safety assessment of ambrisentan based on the FDA Adverse Event Reporting System
Disproportionality analysis of cardiovascular adverse events reported to the FDA adverse event monitoring system with monoclonal antibodies targeting type 2 inflammation
The Trouble With "Antiscience": Regulatory Science, Politics, and the COVID-19 Pandemic
FDA-Approved Drugs for Treatment of Sleep Disorders and Excessive Daytime Sleepinessa
Repurposing FDA approved drugs targeting IL-6 associated signalling for the management of rheumatoid arthritis: an in silico and experimental approach
Vepdegestrant: the first FDA-approved oral PROTAC and a milestone in targeted protein degradation
FDA Approval Summary: Epcoritamab with Lenalidomide and Rituximab for Relapsed or Refractory Follicular Lymphoma
Upcoming FDA approval decisions in Q4 2026
RevMed's RAS inhibitor gains landmark FDA approval for pancreatic cancer
Oncolytic virus nabs FDA approval
Trump's FDA pick Heidi Overton calls vaccines, mifepristone safe and effective in confirmation hearing
Elevar wins FDA nod for bile duct cancer drug Lyrfigtu, a first for a Korean firm
DRUG DISCOVERY
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Perceptive, Nucleus partner to support radiopharmaceutical development
The rise of agentic AI in drug discovery from static tools to autonomous virtual scientists
Proteome-guided drug discovery maps and mitigates therapeutic degrader toxicity
ELRIG and The Protein Society announce keynote speakers for Protein Sciences in Drug Discovery 2026
Carterra advances lab-in-the-loop drug discovery through new scientific collaboration
BioDuro appoints Greg Makara as Senior Vice President Lead Discovery Chemistry to strengthen early drug discovery capabilities
CN Bio announces expert speaker line-up and scientific program for inaugural Organ-on-a-chip e-Symposium
Dr. GPCR and Eurofins Discovery join forces to advance GPCR drug discovery
How Flagship's Valo is reshaping AI drug discovery with human data
Evaluating generative models for structure-based drug discovery from de novo design to lead optimization
A Multi-Scale Computational Framework for Anti-Persister Tuberculosis Drug Discovery
Emerging Roles of Mass Spectrometry-Based Proteomics in Drug Discovery
Implementation of the In Vitro Seizure Liability Assay (iLAseizure) in Drug Discovery and Development: Mechanism of Action Case Studies
From Parasite to Pill: Harnessing Biology for Breakthroughs in Antimalarial Drug Discovery
Composition-structure-activity relationships in Cu x Co1-x Fe2O4 spinel ferrites for visible-light photo-Fenton degradation of rhodamine B
Personalized drug discovery from rare diseases to cancer
Sulfur-doped pine-needle biochar activates peroxymonosulfate for singlet-oxygen-dominated norfloxacin degradation: Structure-activity relationship and mechanistic insights
Design, synthesis, and structure-activity relationships of ω-aryloxy-α-hydroxyalkanoates as selective lateral root inhibitors
Fragment-based drug discovery strategy reveals an unprecedented allosteric binding site in Mycobacterium tuberculosis DNA gyrase
‘A plate of spaghetti’: Talus Bio boasts 5,000-fold faster drug screening by skipping protein folding
INDUSTRY
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Perceptive, Nucleus partner to support radiopharmaceutical development
STAT+: Biotech leader, leading lab leak theorist no longer in consideration for top infectious disease role
Big tech- and pharma-backed Iambic Therapeutics aims for $135m IPO
This week in charts: What’s driving biotech’s recent pullback?
Saudi Arabia's biotech momentum: inside RGMBS 2026
Biohaven partners with Ono in $100m IgG degrader deal
From strong science to mature companies: The next test for Spanish biotech
Top biotech deals in September 2026
ArriVent’s phase 3 lung cancer trial flops, sinking stock
Forbion’s ‘landmark’ €2.3B fundraise to benefit 30 ‘high potential’ biotechs
AstraZeneca hopes to ‘achieve amazing things’ with new Kendall Square R&D center
TRex Bio stomps toward $111M IPO, as Retension and Lycia also gear up to go public
Biotech’s peptide shows promise as ‘bait molecule’ to treat neuropathic pain in mice
The biggest biotech funding rounds in September 2026
Vaxcyte’s stock jumps as pneumococcal vaccine holds its own against Pfizer's, Merck’s shots
Gate CEO sees expanded $870M pact with Lilly as ‘vote of confidence’ in biotech’s platform
‘We’ve been taking our time’: Buzzy AI biotech Xaira reveals antibody platform, first taste of pipeline
BIOSPAIN 2026: The challenge of turning strong science into scale
How Flagship's Valo is reshaping AI drug discovery with human data
Immunotherapy startup Adecto blames ‘risk-averse funding environment’ for closing down
RESEARCH
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Scientists find hidden driver of aging and a simple amino acid that fights memory loss in mice
Scientists discover 5 hidden brain patterns behind depression
A new way to fight gum disease without wiping out good bacteria
Scientists discover a novel strategy to unmask cancer cells in high-risk neuroblastoma
TikTok Flooded With Misinformation After FDA Linked Acetaminophen With Autism
REM sleep paradox: Dreaming may drain the brain’s energy even as fuel supply rises
Stanford scientists discover the human brain may actually be two separate organs
Scientists discover cells that cheat death and rebuild damaged tissue
Hidden “immune organ” in the skull may help fight brain cancer
Scientists find how “zombie” cells fuel inflammation as we age
Scientists discover the human heart can regrow muscle after a heart attack
High blood sugar may help cancer cells hide from the immune system
Scientists find the “Achilles’ heel” of deadly gut bacteria
Scientists discover hidden “footprints of death” that may help viruses spread
The tea in your kombucha changes more than just the taste
Scientists discover why ozempic may not work for some people
Scientists discover simple way to relieve arthritis pain without pills or surgery
Scientists discover vitamin B2 may help cancer cells survive
Your “um” and pauses could reveal early dementia risk
Scientists discover a weak spot shared by polio and common cold viruses
TECHNOLOGY
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Antibody-detecting resistive biosensor for protein biomarkers
Microbial fuel cell biosensors for converting hydroponic root-exudate-derived carbon into electrical signals
Integration of liquid chromatography-tandem mass spectrometry into total laboratory automation: technical challenges and clinical advantages
Cleanroom-Free Microfluidic Chips with Capacitively Coupled 3D Liquid-Metal Electrodes as a Platform Technology for Controlled Electrical Field Stimulation of 2D and 3D Cell Cultures
Oral wearable biosensors in saliva: Antifouling interfaces, device integration, calibration and in-mouth validation
Validating a New-Generation Wrist-Worn Alcohol Biosensor Among Persons With and Without HIV in a Laboratory Setting
Microfluidic pretreatment devices for milk safety at the point of care
Stochastic fiber templating for rapid generation of perfusable microchannels via immersed microfluidic spinning method
Design-dependent shear and liquid media transport characteristics in microfluidic U-shaped cell traps
An integrated microfluidic platform for tunable-stringency competitive affinity selection of folate receptor alpha aptamers
Isomeric effects in propanol and butanol isomers quantified with microwave microfluidic spectroscopy
A cascade catalysis-enhanced microfluidic platform for rapid foodborne pathogen detection using Pt@Zr-MOF nanozymes
Convergent Multi-Omics and Spatial Transcriptomics Identify MCL1 as a Clinically Actionable Mitochondrial Apoptosis Biomarker in Non-Small Cell Lung Cancer
Dual-contrastive learning for spatial domain identification in spatial transcriptomics with STAMGC
An Automated Microfluidic System for Haemostasis Assessment in Cirrhosis With Thrombocytopenia
Multimodal biosensors: a review of signal synergy mechanisms, construction strategies, and application prospects
Characterizing intra- and intertumor heterogeneity in ovarian high-grade serous carcinoma subtypes using single-cell and spatial transcriptomics
Nanostructured ZnO Thin Film-Based Enzymatic Biosensor for Sensitive Acetylcholine Detection in Neurological Applications
A Nanostructured CuO--Enhanced Chemiluminescent Hybrid Microfluidic Platform for Total Cholesterol Biosensing
Label-Free Detection of Thyroid Cancer Biomarkers Using Heterojunction GAA Ferroelectric p-n-i-n TFET Biosensor
CRISPR & GENE EDITING
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Author Correction: UNCOVERseq enables sensitive and controlled gene editing off-target nomination across CRISPR-Cas modalities and systems
A cryptic binding pocket regulates the metal-dependent activity of Cas9
Targeting the gene encoding human T-cell leukemia virus type 1 basic zip factor via CRISPR/Cas9 potentially affects ATL cell survival
Manipulating rRNA levels with CRISPR
CRISPR-based genome editing of smooth muscle cells: Disease models, therapeutic applications, and future perspectives
Correction: CRISPR/Cas9-mediated gene correction of Wilson disease H1069Q point mutation in patient-specific induced pluripotent stem cells
Site-specific RNA photocrosslinking of CRISPR-associated and viral RNA-binding proteins using genetic code expansion
Transposon end recognition and pairing by I-F3 CRISPR-associated transposase
Single-Atom Nanozyme Integrated Double-Clasp Transition Probe-Driven CRISPR/Cas12a Cascade for Preamplification-Free Detection of Non-Nucleic Acid Targets
CRISPR/CAS9-based gene editing in cancer therapy: A systematic review and meta-analysis on current status and future directions
Portable CRISPR/Cas12a-Based Aptasensor System for Point-of-Care Detection of Cytokine Tumor Necrosis Factor-Alpha (TNF-α)
Beyond the Edit: Integrating CRISPR-Cas Genome Editing Into the Cereal Breeding Pipeline
Replicon engineering-driven modular synthetic biology toolkit for efficiently iterative genome editing in Fusarium venenatum
Editing cells in place: Targeted in vivo gene editing of hematopoietic stem cells
Streamlining CRISPR workflows, from editing to analysis
Bigger than CRISPR? A guide to the latest genome editors
CRISPR-based gene drive systems alter the transcriptome in Anopheles gambiae mosquitoes
CRISPR could help doctors attack blood cancer without destroying healthy cells
Author Correction: Tracking-seq: a universal off-target detection approach for CRISPR–Cas genome editing
CRISPR beyond biology: building a sustainable innovation system
CELL & GENE THERAPY
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StockWatch: Caribou Plunges as It Pursues Strategic Alternatives
Parkinson’s cell therapy developer files to go public
Armoring STEAP1 CAR T cells with IL-18 potentiates antitumor activity in Ewing sarcoma
Combating CD24 to overcome CD19 CAR-T resistance via induction of innate and adaptive immunity in B-cell malignancies
Caribou Bio’s Journey With Off-the-Shelf Cell Therapy Reaches the End of the Road
Scientists reprogram immune cells inside the body to fight cancer
CAR T‑Cell Therapy as a Bridging Strategy to Second Transplant in Relapsed B‑Cell ALL
Novartis pens $7.8B deal for Abogen's in vivo autoimmune T-cell engager
Hyponatremia After CAR T-Cell Therapy: Biomarker or Therapeutic Target?
Rapid Manufactured CAR-T Cells enriched for CD45RA-negative T cells Exhibit Superior Persistence Compared to Conventional CAR-T Therapy
An Electronic Frailty Index Is Associated with Outcomes in Older Adults Receiving CAR-T Therapy
Medium-Term Cognitive Outcome in Patients With CNS Lymphomas Treated With Chimeric Antigen Receptor T-Cell Therapy
Tumor cell-intrinsic stress states drive sensitivity to CAR T cell therapy in pancreatic cancer
Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases
ROR1 upregulation after CD19-CAR T-cell relapse in mantle cell lymphoma identifies a targetable vulnerability for ROR1-directed bispecific modalities
PTPN22 as a novel therapeutic target: a key intracellular checkpoint for NK cell therapy
Refractory Chronic Lymphocytic Leukemia Successfully Bridged to CAR T-Cell Therapy Using Splenic Radioembolization
Patient-derived teratomas as a humanized platform for dystrophin restoration by ex vivo cell therapy and in vivo base editing
Author Correction: Bioinstructive implantable scaffolds for rapid in vivo manufacture and release of CAR-T cells
Cellares pens 2nd automation test with Asia-based cell therapy partner in 2 weeks
BIOPRINTING
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Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening
Engineering neurovascular thrombosis: Light-based bioprinting for patient-specific modeling and women's cerebrovascular health
A Reproducible MRI-Based Pipeline for Longitudinal Tracking of Laser-Assisted Bioprinted Cells in Three-Dimensional Constructs
Bioprinting of BSA membranes with C2C12 and NIH 3T3 pre-cellularized PLGA microscaffold: a step toward diaphragmatic hernia patches
Airflow controlled droplet bioprinting enables high-throughput generation of iPSC-derived thymic organoids with in vivo T cell functionality
Microphysiological Systems Integrating Bioprinting, Organoids, Organ-on-a-Chip, and AI: Next Generation Platforms for Pharmaceutical Development
Development of chitosan bioink: Effect of nanocellulose reinforcement in three-dimensional bioprinting applications
Biofabrication of osteochondral composite scaffolds: advances in multi-material bioprinting, functional microenvironment engineering and orthopedic translation
Bioprinted dentin-pulp platform with decoupled mechanics promotes mineralization and vessel-like structures' formation in confined 3D microenvironments
SABER bioprinting: a temporal platform for multiday assembly of engineered tissues
Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications
Spatially compartmentalized fibrotic tumor microtissues via embedded coaxial 3D bioprinting for enhanced barrier function and drug resistance
3D bioprinted human vascular organoid sheets promote functional ischemic repair and exhibit adaptive in vivo remodeling
Weaving Life Into Regolith: Synthetic Autotrophic-Heterotrophic Consortia for Autonomous Biofabrication From Granular Feedstocks
Fabrication of a calcium cement-incorporated composite hydrogel scaffold via extrusion-based 3D bioprinting for bone tissue engineering
Hydrogel Viscoelasticity: Tissue Mechanics, Modulation Strategies, and Bioprinting
A 3D-Bioprinted, Cell-Guiding Hydrogel Patch Promotes Functional Repair of Abdominal Incisions via Anisotropic ECM Remodeling
A New Bioactive Glass-Based Hybrid Bioink With Enhanced Cell Viability and Antibacterial Properties
Cell-laden 3D bioprinted hydrogels for wound healing: cellular mechanism, bioprinting determinants and translational perspectives
PRECISION MEDICINE
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Bridging the pharmacogenomics gap: a survey of healthcare workers in South-Western Nigeria
Advances in radiolabeled antibody technology: optimization strategies for precision medicine
Allopurinol for Marfan Aortopathy: Pharmacogenomic Safety and Sex-Stratified Trial Design Warrant Consideration
Precision medicine requires precision prescribing: rethinking antiseizure medication regulation in Europe
Long-term integrative personalized medicine care in massive brainstem hemorrhage: A CARE-compliant case report
Payers' Views on Expanding Their Role in Precision Medicine
The role of pharmacogenomics in epilepsy treatment: advancements in personalized medicine
Advanced neuroimaging in rare diseases: The paradigm of quantification in the era of personalized medicine
Pharmacogenomics utilization as a tool for deprescribing in Veterans at high-risk for polypharmacy
Precision Oncology at Speed: Workflow Design Determines Clinical Utility in Rapid Molecular Testing for Lung Cancer
Beyond deficiency: micronutrients in the era of precision medicine: are we asking the right questions?
Is exposomics the key to making personalized medicine a reality?
Darier disease international task force: From mechanistic insights to precision medicine
Personalized medicine for lentigo maligna: Beyond 'one knife fits all'?
Precision Oncology in Pediatric Cancer Surgery
Precision Oncology in Soft Tissue Sarcomas and Gastrointestinal Stromal Tumors
Precision Oncology in Melanoma and Skin Cancer Surgery
Precision Oncology in Hepatopancreatobiliary Cancer Surgery
Precision Oncology in Gastrointestinal and Colorectal Cancer Surgery
Toward precision psychiatry: integrating pharmacogenomics and multimodal clinical data for personalized antidepressant response prediction
STEM CELLS
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Priming of human iPSCs with doxorubicin causes genome-wide transcriptional reprogramming and functional impairments in iPSC-derived cardiomyocytes
Transcriptomic profiling of human iPSC-derived Schwann-like cells reveals NF2-regulated gene regulatory networks
New signaling pathway enhances blood stem cell transplantation outcomes
New BCR analysis method tracks immune recovery after stem cell transplantation
Peri-transplant ruxolitinib in myelofibrosis patients undergoing αβTCR and CD19-depleted stem cell transplantation
Human iPSC-Derived Tissue-Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model
Correction: CRISPR/Cas9-mediated gene correction of Wilson disease H1069Q point mutation in patient-specific induced pluripotent stem cells
Assessment of acute functional effects of perfluorooctanoic acid (PFOA), heptafluorobutyric acid (HFBA), and hexafluoropropylene oxide dimer acid (HFPO-DA) in human iPSC-derived cardiomyocytes using multielectrode arrays
From patient cells to patient therapy: Twenty years of iPSC-based translation in neurodegenerative disease
Electro-mechanical stimulation during differentiation of neural stem cells derived from human induced pluripotent stem cells enhances neuronal network organization and activity
A human-induced pluripotent stem cell-derived spheroid model to investigate myelin injury and repair
A human-induced pluripotent stem cell-derived spheroid model to investigate myelin injury and repair
Voices: What impact has iPSC technology had on your research and/or field?
Fetal signatures in the 3D genome of iPSC-derived neurons and their implications for disease modeling
Hidden Outcomes of CRISPR-Cas9 Genome Editing Revealed by Targeted Sequencing in Isogenic Human iPSC Clones
Airflow controlled droplet bioprinting enables high-throughput generation of iPSC-derived thymic organoids with in vivo T cell functionality
Improving the differentiation capability of porcine induced pluripotent stem cells by using the additional reprogramming factor TBX3
A human iPSC-based perfusable and membrane-free neurovascular unit-on-chip connecting brain organoids to the blood-brain barrier
Correction: Secondary autoimmune and inflammatory diseases after allogeneic hematopoietic stem cell transplantation: a retrospective study from the EBMT transplant complications and autoimmune diseases working parties
Stem cells reverse stroke damage and restore movement in mice
NEW APPROACH METHODS
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New approach methodologies to model the female reproductive tract: advances and opportunities for nanomedicine
Advancing component-based mixture risk assessment using new approach methodologies: An environmental case study
Pediatric Developmental Safety Assessment and New Approach Methodologies: US FDA/Triangle CERSI Workshop Report
New Approach Methodologies in Pharmaceutical Development: Survey Insights on Adoption, Infrastructure, and the Path to Broader Implementation
Quinoa and Peanut Extracts as Alternatives to Animal-Derived Extracellular Matrix Proteins in Cultured Meat Production
New approach methodologies for in vitro detection of chemical-induced cholestatic liver injury
Human placental transfer of xenobiotics in health and disease: New approach methodologies for developmental and reproductive toxicology testing and mathematical modelling
AI-integrated human-relevant alternatives to animal experimentation in drug development: Toward a predictive translational ecosystem, from in vitro and in silico models to clinical and real-world evidence
New approach methodologies: drug screening platform to identify antifibrotic compounds
Strategic application of New Approach Methodologies (NAMs) in fragrance ingredient safety assessment: Integration of in vitro, in silico, and exposure-based approaches in RIFM evaluations
Harnessing Yarrowia lipolytica as a platform for animal-free and secretory production of human lactoferrin
Editorial: Advancing in vitro cell culture practices: achieving truly animal-free experiments and scientifically reliable and reproducible methods
Eleutheroembryo-based new approach methodologies for endocrine and metabolic endpoints: a comment on Christou et al. (2026)
Patient-Derived 3D Cell Models as New Approach Methodologies: Applications, Advances, and Challenges for Increased-Throughput Assays
Advancing Regulatory Adoption of New Approach Methodologies
New approach methodologies in neurotherapeutics development
Animal reuse in safety assessment studies: a review of current practices, challenges and 3Rs opportunities
Finding a place for new approach methodologies (NAMs) in biomedical research
All things are active … new approach methods for excipient safety
FUNDING & VC
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Outro Raises $7M To Support Safe Deprescribing
Big tech- and pharma-backed Iambic Therapeutics aims for $135m IPO
Viatris boosts pain drug portfolio with $1.7B buyout of Pacira
Top biotech deals in September 2026
The biggest biotech funding rounds in September 2026
The 50 best-funded biotech companies of 2026
IMMUNOTHERAPY
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NHS Blood and Transplant partners with Northwest Biotherapeutics
Bowel cancer “melted away” after immunotherapy, then stayed away
Epithelial–mesenchymal transition in immune escape and immunotherapy resistance of lung cancer
Roche’s Tecentriq snags FDA label expansion in type of colon cancer
Cancer-fighting t cells burn out. Scientists may have found a fix
Genmab’s latest phase 2 data spur claim ADC is ‘clearly superior’ to AbbVie’s Elahere
Real-world utilization of immune checkpoint inhibitors in medicare-eligible patients with triple-negative breast cancer in the United States
Beyond Contraindication-Based Selection: The Unmet Need for Predictive Biomarkers in First-Line Immunotherapy for Advanced HCC
Development of bi-functional hybrid IgGA antibodies for enhancing cancer immunotherapy
Iterative Optimization of Photoactivatable BRD4 Degraders for Aging-Amplified Immunotherapy in Patient-Derived Lung Cancer Organoids
Thrombotic rates in individuals with inherited bleeding disorders treated with concentrate or bispecific antibody. Fifteen-year EUHASS data
Treatment sequence after first-line immunotherapy in older adults with advanced NSCLC (NEJ057)
Engineering IL-4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Immunotherapy startup Adecto blames ‘risk-averse funding environment’ for closing down
Self-Assembling Peptide-Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy
Structural DNA nanotechnology-guided spatially-ordered arrangement of aptamers on natural killer cells for solid tumor immunotherapy
A systemic-absorption-blocked (SEAL) nanoplatform for mRNA-based local immunotherapy
Optimizing antibody-dependent cellular phagocytosis for cancer immunotherapy: mechanisms, constraints, and therapeutic strategies
Peanut Oral Immunotherapy in a High-Volume Tertiary Allergy Center: Experience and Outcomes
Scientists find new way to overcome cell’s natural defenses against self-amplifying mRNA vaccines
MICROBIOME
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Extracts of okra mucilage protect intestinal homeostasis through gut microbiota and immune responses
Colon-targeted delivery of α-terpineol via ZIF-8 alleviates ulcerative colitis by anti-inflammatory and gut microbiota-metabolism modulation
Forsythiae Fructus polysaccharides mitigate DSS colitis by modulating gut microbiota-derived palmitic acid and PI3K/AKT pathway
Age-related shifts in the salivary microbiome linked to cariogenic changes: A cross-sectional study
Aromaticity Engineering of Hybrid Cyanine Dyes for Metabolic Labeling and Bioorthogonal NIR-II Imaging of Gut Microbiota
Microbiome signatures and mechanistic pathways in pediatric obesity: from early-life risk to precision interventions
Clinical Landscape of Microbiome Modulators in Gynecological Tumor Treatment: From Pre-Clinical to Clinical Trials
A branched α-glucan from Galli Gigeriae Endothelium Corneum alleviates high-fat diet-induced obesity in a gut microbiota-dependent manner
Salivary microbiome responses to chlorhexidine and Coriandrum sativum essential oil mouthwashes in patients with periodontitis in a randomized 2-week clinical trial
Next-generation probiotics and microbiome-based therapeutics highlighting Akkermansia muciniphila and Amuc_1100
Evaluating Vaginal Microbiome Effects on Antiretroviral Exposure in the Female Genital Tract Using Pharmacometric and Machine Learning Approaches
A cross-families evaluation of using fecal samples as a method to study the amphibian gut microbiome
Gut microbiota and systemic sclerosis: Mechanistic insights and microbial therapies
Chinese yam polysaccharide attenuates DSS-induced ulcerative colitis by modulating gut microbiota and eicosanoid metabolism
Protected area management contexts are associated with variation in Tibetan macaque gut microbiota and antibiotic resistomes
The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome
Crude Corbicula fluminea carbohydrate extract attenuates cyclophosphamide-induced immune and intestinal injury in mice in association with gut microbiota remodeling
Genome mining of the tumor microbiome reveals biosynthetic diversity and potential pathology-modulating metabolites
Sugar-rich foods exacerbate antibiotic-induced microbiome disruption
Drug–microbiome–host interactions: antimicrobial effects of non-antibiotic compounds
CARDIOVASCULAR
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Active abdominal compression-decompression cardiopulmonary resuscitation versus standard cardiopulmonary resuscitation for adult cardiac arrest: a systematic review and meta-analysis
Semaglutide, independent of weight loss, attenuates cardiac and hepatic remodelling in experimental heart failure with preserved ejection fraction
Training the diaphragm as a pillar of cardiac rehabilitation in heart failure
Weekly Journal Scan: Expanding the therapeutic options for adolescents with obstructive hypertrophic cardiomyopathy
Measuring a moving target: analytic considerations for atrial fibrillation density
Atrial fibrillation density and stroke risk: a promising advance that now needs predictive validation
Recurrent myocarditis masquerading as acute myocardial infarction: unmasking Behçet's disease
Park Proximity and Emergency Department Visit Rates for Asthma and Acute Myocardial Infarction in Los Angeles County: A Cross-Sectional Ecological Study
Fatal Dilated Cardiomyopathy and Monogenic Diabetes Mellitus as SMPD4-Related Disorder
E-Cigarette Perceptions Among Adults with Recent Myocardial Infarction or Heart Failure Diagnosis: Population Assessment of Tobacco and Health Study, 2022-2023
Targeted delivery of the CB2 receptor agonist JWH-133 via VCAM-1-functionalised nanoparticles attenuates atherosclerosis and reveals sex-specific therapeutic outcomes
Left Atrial Appendage Occlusion Among Cancer Patients with Atrial Fibrillation: a systematic review and update meta-analysis
Cardiomyocyte Membrane-Camouflaged Spinach Nano-Thylakoids Enhance Myocardial Energy Metabolism and Ameliorate Heart Failure
In-Hospital Guideline-Directed Medical Therapy Intensification and Long-Term Outcomes in Patients Hospitalized for Heart Failure in the Current Clinical Paradigm - Insights From the QHEART-R Study
Proton Pump Inhibitor Co-prescription, Dabigatran Use, and Ischaemic Stroke or Transient Ischaemic Attack in Atrial Fibrillation: A Population-Based Case-Control Study
miR-454-3p alleviates LPS-induced cardiomyocyte damage by negatively regulating STAT3 in sepsis-induced cardiomyopathy
Metabolomic biomarkers and metabolic remodelling in genetically characterised hypertrophic cardiomyopathy: a systematic review
Frailty-Related Metabolic Signature in the Association Between Frailty and Coronary Artery Disease: Modification by Genetic Susceptibility
Chronic sleep deprivation promotes atherosclerosis via NFIL3/RORγt Axis mediated Th17/Treg imbalance, targeting IL-17A attenuates disease progression
Clinical relevance of lead-induced tricuspid regurgitation after transvenous ICD implantation in arrhythmogenic cardiomyopathy
ONCOLOGY
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More options, better odds: the changing prostate cancer treatment landscape
The conformation-selective PI3Kδ inhibitor roginolisib in patients with advanced or metastatic cancer, including metastatic uveal melanoma: first-in-human clinical trial
Scientists just found a way to fight lung cancer and muscle wasting at the same time
Advances in 3D Bioprinting for Breast Cancer Modeling: Tumor Microenvironment, Metastasis, and Drug Screening
Oncolytic virus encoding decorin and the CD40 ligand boosts T-cell response and achieves a durable antitumor response during breast cancer treatment
Vitamin D drug may help crack pancreatic cancer’s protective shield
Immune-Cell Dynamics in the Tumor Microenvironment: Implications for Cancer Therapy
Liver Metastases from Colorectal Cancer: From Pathogenesis to Current Treatment
Envonalkib Versus Crizotinib in Treatment-Naive ALK-Positive Non-Small Cell Lung Cancer: Final Efficacy and Biomarker Analyses of the Randomized Phase III Study
Cost-effectiveness analysis of penpulimab plus anlotinib versus sorafenib as first-line therapy for advanced hepatocellular carcinoma
Cell-Free DNA as a Biomarker of Cell Death and Treatment Response for On-Chip Three-Dimensional Tumor Models
Neoadjuvant treatment or chemoselection in head and neck carcinoma. What makes one term different from another
Disitamab vedotin in urothelial carcinoma patients: a clinical trial perspective from ARON working group
Repeated remimazolam sedation for interstitial brachytherapy in cervical cancer: a randomized controlled trial
Raman Self-Tracking Copper Metal-Organic Framework-Based Nanoplatform for Cuproptosis Cancer Therapy
Scientists say house cats could help unlock better cancer treatments for humans
A major risk of breast cancer screening may have been overestimated for decades
Elevar wins FDA nod for bile duct cancer drug Lyrfigtu, a first for a Korean firm
This new drug could break cancer’s resistance to treatment
Bayer offloads cancer drug Stivarga to Grünenthal for up to $431M as new competition looms
NEUROSCIENCE
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Genome-wide analysis of common structural variants in Alzheimer’s disease identifies a risk-associated regulatory CCG repeat in FAM193B
The hidden math of Alzheimer's could point to new treatments
Managing misfolded proteins to prevent Parkinson’s disease
Genentech pays Alector $100M for preclinical Parkinson’s prospect
Effect of Continuous Subcutaneous Foslevodopa/Foscarbidopa Infusion on Parkinson's Disease-Related Pain: A 6-Month Real-World Longitudinal Study
Cerebrospinal fluid inflammatory proteomic profiling identifies biomarkers linked to disease progression in amyotrophic lateral sclerosis
Impact of group singing on communication and quality of life in individuals with Parkinson's disease: A qualitative study
Social media utilization to understand the journey and unmet needs of patients with Parkinson's disease in the Philippines
Association between BDNF methylation and expression of the NLRP3 inflammasome in the brain is disrupted in Alzheimer's disease
The safety and tolerability of opicapone in elderly Parkinson's disease patients: a real-world, multicenter, retrospective study
Therapeutic potential of proline-rich peptide-1 (PRP-1) in counteracting amyloid-β-mediated cortical and hippocampal neurodegeneration in a rat model
A statistical framework for integrative imaging genomics with biclustering and ensemble penalized regression in Alzheimer's disease
Multimodal neuroimaging in dementia and neurodegenerative disorders: complementary roles of clinically available nuclear medicine and MRI in the era of disease-modifying therapies
The immunoproteasome in Alzheimer's disease: a dual regulator of tau pathology and microglial senescence
Stem cells and derived growth factors in Alzheimer's disease: mechanistic insights and translational perspectives
The Therapeutic Potential of MicroRNAs Delivered By Mesenchymal Stem Cells in Parkinson's Disease, Alzheimer's Disease, and Stroke: A Systematic Review of Preclinical Studies
Exploring the role of glymphatic system in Alzheimer's disease with insights from MRI-based studies: a systematic review
Effects of food-drug interaction-oriented nutritional education on quality of life in Parkinson's disease: A pilot quasi-experimental study
Movement Disorder Society Unified Parkinson's Disease Rating Scale Part III cannot Be Reliably Reduced for Predicting Time to Initiation of Parkinsonian Medication in Early Parkinson's Disease: An Item-Level Sensitivity Analysis
Scientists find a new layer of Alzheimer’s hidden in the genome
INFECTIOUS DISEASE
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Safety and immunogenicity of a BPL-inactivated, whole-virus, universal influenza vaccine: a randomized, double-blinded, double-dummy, placebo-controlled, phase 1 clinical trial
Bioengineering strategies for improving the immunogenicity of mRNA vaccines
Estimation of the relative effectiveness and waning of the monovalent third dose of COVID-19 vaccine against hospital admission in France: a novel self-controlled case series analysis
HPV vaccine series completion in a midwestern HIV/PrEP population
Validation of the behavioural and social drivers of influenza vaccine survey in Australia: Cognitive interviews and psychometric evaluation
Managing urinary tract infections in pregnancy: teratogenic risks, molecular mechanisms, and antibiotic safety
A Thermosensitive Mucoadhesive Hydrogel for Nasal Influenza Vaccine Delivery Elicits Robust Systemic and Mucosal Immunity
Combining Antiviral Therapy with Cancer Treatment in HBV-associated HCC: A Translational Approach
Can Moderna's mRNA cancer vaccine for cutaneous melanoma be applicable to melanomas of the eye and ocular adnexa?
Real-world safety of dengue vaccines in Brazil: A pharmacovigilance study
Evaluation of Three Recombinant Live-Attenuated Respiratory Syncytial Virus Vaccines RSV/ΔNS2/Δ1313/I1314L, RSV/6120/ΔNS2/1030s, and RSV/276 in RSV Seronegative Children
Safety Monitoring of COVID-19 Vaccines in the Vaccine Adverse Event Reporting System (VAERS): United States, August 22, 2024-July 4, 2025
Computational systems immunology and multi-scale modeling for the design of a Multi-Epitope Vaccine (MEV) against emerging multidrug-resistant Klebsiella michiganensis
Immunopharmacological design of a multi-epitope vaccine targeting hepatitis C virus genotype 3a
External validation of the KLIC score and development of a novel prediction model for debridement, antibiotics, and implant retention failure in prosthetic joint infection: a multicentre cohort study
Scientists find new way to overcome cell’s natural defenses against self-amplifying mRNA vaccines
160-million-year-old proteins show surprising power against superbugs
AI-guided optimization for thermostable mRNA vaccines
Recoding by N1-methylpseudouridine guides rational mRNA vaccine design
Extended dosing intervals enhance the durability of a self-amplifying mRNA vaccine against pandemic H5N1 influenza: a randomized, observer-blind, dose-finding Phase I study
LIQUID BIOPSY
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Cell-Free DNA as a Biomarker of Cell Death and Treatment Response for On-Chip Three-Dimensional Tumor Models
Clinical Performance Evaluation of Size-Selective Placental Cell-Free DNA Enrichment for Non-Invasive Prenatal Testing of Fetal Copy Number Variants
Early experience with cerebrospinal fluid cell-free DNA molecular profiling in a neuro-oncology practice
Cell-free DNA fragmentomics: from chromatin biology to clinical stratification
Kidney-specific cell-free DNA as biomarker of kidney injury: Development and exploration of a multiplex digital droplet PCR assay
Liquid biopsy for early detection and biomarker applications in gynecological cancers: current status and future directions
Liquid biopsy in head and neck tumors: novel approaches and clinical applications
Tumor-Free Circulating Tumor DNA in Node-Negative Rectal Cancers Undergoing Neoadjuvant Chemotherapy, Excision, and Observation in the Phase II NEO Trial (CO.28)
Cell Free DNA Whole Genome in Clinical Practice: A Single Center Seven-Year Experience
Organ-specific liquid biopsy in lung cancer: the emerging role of exhaled breath condensate
Longitudinal liquid biopsy and matched radiomic analysis indicated resistance mechanisms of patients with biliary tract cancer undergoing systemic treatment
Serial ctDNA Analysis for Monitoring Molecular Response and Acquired Resistance in Metastatic NSCLC and HR+/HER2-Negative Breast Cancer: A Real-World Study
Diagnostic Performance of Donor-derived Cell-free DNA Combined With Immune Activation Markers for Detecting Acute Rejection After Liver Transplantation
Unveiling the Prognostic Power of Circulating Tumor DNA in Multiple Myeloma: A Systematic Review and Updated Meta-Analysis
ctDNA Profiling Identifies Daraxonrasib Resistance Mechanisms
One-pot SP-EXPAR-integrated CRISPR/Cas14a assay for highly specific and versatile detection of ctDNA mutations in lung cancer patients
ASO Visual Abstract: Recurrence in Real Time: Rethinking Breast Cancer Follow-Up with Circulating Tumor DNA
ASO Visual Abstract: Preoperative Tumor-Informed ctDNA for Prediction of Nodal Metastases at Radical Cystectomy in Bladder Cancer
Liquid Biopsy in Biliary Tract Cancer: When Tissue Is Not Enough
AI blood test finds silent liver disease years before symptoms