Patient Analog Framework
The hierarchical architecture integrating human simulation technologies
System Hierarchy
Whole-Patient Digital Twin
Complete patient simulation integrating all organ systems for personalized treatment prediction.
Multi-Organ Systems
Connected organ models simulating systemic drug distribution, metabolism, and excretion.
Single Organ Models
Organ-on-chip and organoid platforms representing individual organ function.
Tissue and Cell Systems
3D cell cultures, spheroids, and tissue constructs for cellular-level analysis.
Molecular and Pathway Models
Computational models of molecular interactions, signaling pathways, and protein structures.
Data Flow
Biological Data
Genomic, proteomic, and metabolomic data from patient samples feeds computational models.
Experimental Outputs
Real-time data from organ-on-chip sensors and organoid imaging validates predictions.
Clinical Correlation
Patient outcome data refines models and improves predictive accuracy over time.
Regulatory Alignment
Standardized data formats enable submission to FDA, EMA, and other regulatory bodies.
Framework Use Cases
Drug Safety
Predict hepatotoxicity, cardiotoxicity, and nephrotoxicity before clinical trials.
Efficacy Prediction
Identify patient populations likely to respond to specific therapeutics.
Dose Optimization
Determine optimal dosing regimens using PKPD modeling and patient-specific factors.
Disease Modeling
Recreate disease states to understand mechanisms and identify drug targets.